Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
| ▸ | RARG | P13631 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8227731 | 0.83 | HDAC1 (0.50) | HDAC1RARBRARGSRD5A2RAB9A | |
| SCHEMBL6280933 | 0.79 | HDAC1 (0.50) | HDAC1RARBRARGSRD5A2RAB9A | |
| SCHEMBL20258185 | 0.79 | NOS3 (0.44) | RAB9AALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL2892447 | 0.79 | ALDH1A1 (0.48) | HDAC1SRD5A2RAB9AALDH1A1MEN1 | |
| SCHEMBL5690957 | 0.78 | HDAC1 (0.57) | HDAC1RARBRARGSRD5A2RAB9A | |
| SCHEMBL5242548 | 0.76 | TSHR (0.52) | SRD5A2ALDH1A1KMT2ASMN1; SMN2CA1 | |
| SCHEMBL1029779 | 0.76 | MAPT (0.46) | SRD5A2RAB9AALDH1A1HTTKMT2A | |
| SCHEMBL14879115 | 0.75 | HDAC1 (0.53) | HDAC1RARBRARGSRD5A2RAB9A | |
| SCHEMBL14879101 | 0.75 | HDAC1 (0.53) | HDAC1RARBRARGSRD5A2RAB9A | |
| SCHEMBL572232 | 0.75 | CES2 (0.48) | RAB9AALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162862-A1 | INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-06-14 | — | — | US | disclosed |
| US-20180162862-A1 | INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-06-14 | — | — | US | disclosed |
| US-9968571-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-9968571-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-9968571-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| EP-3303338-A1 | INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES | President and Fellows of Harvard College (US) | 2018-04-11 | — | — | EP | disclosed |
| US-20170128393-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2017-05-11 | — | — | US | disclosed |
| US-20170128393-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2017-05-11 | — | — | US | disclosed |
| US-20170128393-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2017-05-11 | — | — | US | disclosed |
| US-9566254-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC. (US) | 2017-02-14 | — | — | US | disclosed |
| US-20130195796-A1 | Inhibitors and Methods of Inhibiting Bacterial and Viral Pathogens | SIGA TECHNOLOGIES INC. (US) | 2013-08-01 | — | — | US | disclosed |
| US-20130195796-A1 | Inhibitors and Methods of Inhibiting Bacterial and Viral Pathogens | SIGA TECHNOLOGIES INC. (US) | 2013-08-01 | — | — | US | disclosed |
| EP-2583962-A2 | NOVEL THIOUREA OR UREA DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AIDS, CONTAINING SAME AS ACTIVE INGREDIENT | Avixgen Inc. (KR) | 2013-04-24 | — | — | EP | disclosed |
| US-20130096138-A1 | NOVEL THIOUREA OR UREA DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AIDS, CONTAINING SAME AS ACTIVE INGREDIENT | AVIXGEN INC. (KR) | 2013-04-18 | — | — | US | disclosed |
| WO-2011103375-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2011-01-27 | — | — | US | disclosed |
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2011-01-27 | — | — | US | disclosed |
| EP-2099445-B1 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIV DUNDEE (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2008029096-A2 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2008-03-13 | — | — | WO | disclosed |
| US-5021412-A | Protecting agricultural crops | MITSUI TOATSU CHEMICALS, INC. (JP) | 1991-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130195796-A1 | Inhibitors and Methods of Inhibiting Bacterial and Viral Pathogens | TST, TPMT, EIF2AK2 | HDAC1 142/4885RARB 2851/4885RARG 3571/4885 |
| US-20170128393-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | TST, TPMT, EIF2AK2 | HDAC1 142/4885RARB 2851/4885RARG 3571/4885 |
| US-20180162862-A1 | INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES | SI, UGGT1, ALPI | HDAC1 709/4885RARB 4329/4885RARG 4127/4885 |
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | TP53, TP53BP1, SIRT1 | HDAC1 156/4885RARB 624/4885RARG 536/4885 |
| US-20130096138-A1 | NOVEL THIOUREA OR UREA DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AIDS, CONTAINING SAME AS ACTIVE INGREDIENT | UGP2, TPMT, UPP1 | HDAC1 2069/4885RARB 3747/4885RARG 3920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.