Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.64 |
| ▸ | MMP9 | P14780 | 11/20 | 0.64 |
| ▸ | MMP12 | P39900 | 11/20 | 0.64 |
| ▸ | MMP14 | P50281 | 10/20 | 0.64 |
| ▸ | MMP13 | P45452 | 10/20 | 0.64 |
| ▸ | MMP8 | P22894 | 9/20 | 0.64 |
| ▸ | MMP16 | P51512 | 8/20 | 0.64 |
| ▸ | MMP1 | P03956 | 8/20 | 0.64 |
| ▸ | MMP3 | P08254 | 8/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28306756 | 0.72 | L3MBTL1 (0.59) | MMP2MMP9MMP12MMP14MMP13 | |
| SCHEMBL10049375 | 0.71 | MMP12 (0.50) | MMP2MMP9MMP12MMP14MMP13 | |
| SCHEMBL10049383 | 0.71 | TSHR (0.48) | MMP2MMP9MMP12MMP14MMP13 | |
| SCHEMBL8222695 | 0.70 | MMP12 (0.61) | MMP2MMP9MMP12MMP14MMP13 | |
| SCHEMBL2649397 | 0.70 | MMP2 (0.46) | MMP2MMP9MMP12MMP14MMP13 | |
| SCHEMBL9228368 | 0.68 | MMP2 (0.82) | MMP2MMP9MMP12MMP14MMP13 | |
| SCHEMBL28251552 | 0.68 | ADAMTS4 (0.52) | MMP2MMP9MMP12MMP14MMP13 | |
| SCHEMBL8485346 | 0.68 | MMP9 (0.74) | MMP2MMP9MMP12MMP14MMP13 | |
| SCHEMBL8492008 | 0.68 | MMP9 (0.74) | MMP2MMP9MMP12MMP14MMP13 | |
| SCHEMBL372276 | 0.67 | CYP1A2 (0.57) | CYP1A2TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | disclosed |
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | disclosed |
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | BRACCO IMAGING SPA (IT) | 2009-09-24 | — | — | US | disclosed |
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | BRACCO IMAGING SPA (IT) | 2009-09-24 | — | — | US | disclosed |
| WO-2008015139-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | BRACCO IMAGING SPA (IT) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | SERPINB1, ZFX, MMP2 | MMP2 3/4885MMP9 8/4885MMP12 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.