Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.58 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.57 |
| ▸ | CFTR | P13569 | 4/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.54 |
| ▸ | GABRP | O00591 | 1/20 | 0.52 |
| ▸ | GABRD | O14764 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452910 | 1.00 | MEN1 (0.65) | MEN1KMT2ANPC1CYP1A2HPGD | |
| SCHEMBL398270 | 0.90 | CFTR (0.69) | MEN1KMT2ANPC1CYP1A2HPGD | |
| SCHEMBL3430255 | 0.86 | RAB9A (0.68) | MEN1KMT2ANPC1GABRPGABRD | |
| SCHEMBL23205512 | 0.86 | HDAC1 (0.54) | MEN1KMT2ANPC1NHERF1EPHB3 | |
| SCHEMBL29988302 | 0.86 | HDAC1 (0.54) | MEN1KMT2ANPC1NHERF1EPHB3 | |
| SCHEMBL20567854 | 0.85 | NPC1 (0.68) | MEN1KMT2ANPC1NHERF1CFTR | |
| SCHEMBL27075304 | 0.84 | NPC1 (0.68) | MEN1KMT2ANPC1NHERF1CFTR | |
| SCHEMBL92581 | 0.84 | RAB9A (0.64) | MEN1KMT2ANPC1NHERF1CFTR | |
| SCHEMBL31010176 | 0.82 | NPC1 (0.65) | MEN1KMT2ANPC1NHERF1CFTR | |
| SCHEMBL20567514 | 0.82 | NPC1 (0.65) | MEN1KMT2ANPC1NHERF1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125351-A1 | COMPOUND FOR INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO AND USE THEREOF | KLOTHO SCIENCES (KR) | 2026-05-07 | — | — | US | disclosed |
| US-12545653-B2 | Compound as PPAR agonist and application thereof | USA Elixiria Biotech Inc. (US) | 2026-02-10 | — | — | US | disclosed |
| US-20240358683-A1 | COMPOSITION FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASE COMPRISING COMPOUND INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO | KLOTHO SCIENCES (KR) | 2024-10-31 | — | — | US | disclosed |
| US-20240216341-A1 | COMPOSITION FOR PREVENTING OR TREATING CHRONIC KIDNEY DISEASE, COMPRISING COMPOUND THAT INDUCES EXPRESSION OF ANTI-AGING GENE KLOTHO | KLOTHO SCIENCES (KR) | 2024-07-04 | — | — | US | disclosed |
| US-20240216341-A1 | COMPOSITION FOR PREVENTING OR TREATING CHRONIC KIDNEY DISEASE, COMPRISING COMPOUND THAT INDUCES EXPRESSION OF ANTI-AGING GENE KLOTHO | KLOTHO SCIENCES (KR) | 2024-07-04 | — | — | US | disclosed |
| US-20240216341-A1 | COMPOSITION FOR PREVENTING OR TREATING CHRONIC KIDNEY DISEASE, COMPRISING COMPOUND THAT INDUCES EXPRESSION OF ANTI-AGING GENE KLOTHO | KLOTHO SCIENCES (KR) | 2024-07-04 | — | — | US | disclosed |
| US-20240189278-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. | 2024-06-13 | — | — | US | disclosed |
| CN-114502541-B | Compounds inducing expression of anti-aging gene KLOTHO and application thereof | 克洛索科学公司 | 2024-06-07 | — | — | CN | disclosed |
| EP-4316487-A1 | COMPOSITION FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASE COMPRISING COMPOUND INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO | Klotho Sciences (KR) | 2024-02-07 | — | — | EP | disclosed |
| EP-4317140-A1 | COMPOSITION FOR PREVENTING OR TREATING CHRONIC KIDNEY DISEASE, COMPRISING COMPOUND THAT INDUCES EXPRESSION OF ANTI-AGING GENE KLOTHO | Klotho Sciences (KR) | 2024-02-07 | — | — | EP | disclosed |
| EP-4039676-A1 | COMPOUND FOR INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO AND USE THEREOF | Klotho Sciences (KR) | 2022-08-10 | — | — | EP | disclosed |
| CN-114502541-A | Compound for inducing expression of anti-aging gene KLOTHO and application thereof | 克洛索科学公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-114409680-A | PPAR agonist and application thereof | 上海怡立舍生物技术有限公司 | 2022-04-29 | — | — | CN | disclosed |
| CN-108250058-B | PPAR agonists and their use in the treatment of Alzheimer's disease and other diseases | 上海怡立舍生物技术有限公司 | 2022-02-11 | — | — | CN | disclosed |
| EP-3883958-A1 | METHODS AND MATERIALS FOR REDUCING AGE-RELATED STRIATED MUSCLE AND COGNITIVE DECLINE | University of Pittsburgh - Of the Commonwealth System of Higher Education (US) | 2021-09-29 | — | — | EP | disclosed |
| WO-2021066608-A1 | COMPOUND FOR INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO AND USE THEREOF | 주식회사 클로소사이언스 | 2021-04-08 | — | — | WO | disclosed |
| US-20200331868-A1 | COMPOUND AS PPAR AGONIST AND APPLICATION THEREOF | USA Elixiria Biotech Inc. | 2020-10-22 | — | — | US | disclosed |
| WO-2019141229-A1 | COMPOUND AS PPAR AGONIST AND APPLICATION THEREOF | 上海怡立舍生物技术有限公司 | 2019-07-25 | — | — | WO | disclosed |
| US-20180338951-A1 | TREATMENTS FOR ARTERIAL STIFFENING, HYPERTENSION AND ANTI-AGING | KLOTHO THERAPEUTICS, INC. | 2018-11-29 | — | — | US | disclosed |
| US-20030153754-A1 | Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands | NEUROGEN CORPORATION, A CORPORATION OF THE STATE OF DELAWARE | 2003-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12545653-B2 | Compound as PPAR agonist and application thereof | PPARA, PPARD, PPARG | MEN1 4876/4885KMT2A 3604/4885NPC1 1976/4885 |
| US-20240358683-A1 | COMPOSITION FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASE COMPRISING COMPOUND INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO | CTSA, GLA, KLF5 | MEN1 3736/4885KMT2A 1068/4885NPC1 278/4885 |
| US-20240216341-A1 | COMPOSITION FOR PREVENTING OR TREATING CHRONIC KIDNEY DISEASE, COMPRISING COMPOUND THAT INDUCES EXPRESSION OF ANTI-AGING GENE KLOTHO | GLA, CTSA, FGF23 | MEN1 4725/4885KMT2A 1295/4885NPC1 1512/4885 |
| US-20260125351-A1 | COMPOUND FOR INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO AND USE THEREOF | GLA, CTSA, KLF5 | MEN1 4251/4885KMT2A 571/4885NPC1 1150/4885 |
| US-20240189278-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | COL2A1, COL1A1, COL14A1 | MEN1 1555/4885KMT2A 442/4885NPC1 3649/4885 |
| US-20200331868-A1 | COMPOUND AS PPAR AGONIST AND APPLICATION THEREOF | PPARA, PPARG, PPARD | MEN1 4863/4885KMT2A 3749/4885NPC1 785/4885 |
| US-20180338951-A1 | TREATMENTS FOR ARTERIAL STIFFENING, HYPERTENSION AND ANTI-AGING | COL2A1, COL1A1, COL14A1 | MEN1 519/4885KMT2A 1244/4885NPC1 4496/4885 |
| US-20030153754-A1 | Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands | GABRB1, GABRB3, GABRB2 | MEN1 4750/4885KMT2A 1954/4885NPC1 1723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.