Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.47 |
| ▸ | HTR3B | O95264 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 2/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | REN | P00797 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305730 | 0.82 | REN (0.51) | REN | |
| SCHEMBL13344705 | 0.78 | ADRB1 (0.53) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL6717105 | 0.78 | REN (0.58) | REN | |
| SCHEMBL6720057 | 0.75 | L3MBTL1 (0.51) | CYP2C19MAPTLMNAHTR1AMAPK1 | |
| SCHEMBL5234835 | 0.75 | SIGMAR1 (0.45) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL10305090 | 0.74 | ADRB1 (0.46) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL22638141 | 0.74 | KIT (0.57) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL8858015 | 0.73 | ADRB1 (0.61) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL7483034 | 0.72 | LTA4H (0.67) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL3108154 | 0.72 | ADRB1 (0.45) | HTR3EHTR3BADRB1HTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089915-A1 | PIPERAZINE DERIVATIVE RENIN INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |