Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306140 | 0.77 | KDM4E (0.39) | HRH3ITGB3ITGA2BCYP2C9 | |
| SCHEMBL8304068 | 0.77 | CYP2D6 (0.39) | ITGB3ITGA2BHRH1CYP2C9 | |
| SCHEMBL8300007 | 0.76 | HSD11B1 (0.32) | ITGB3ITGA2B | |
| SCHEMBL8298757 | 0.76 | HRH3 (0.49) | HRH3ITGB3ITGA2BEPHX2CYP2C9 | |
| SCHEMBL8617676 | 0.74 | HRH3 (0.46) | HRH3EPHX2HRH1CCR3 | |
| SCHEMBL8300039 | 0.72 | ITGB3 (0.40) | ITGB3ITGA2BCYP2C9 | |
| SCHEMBL639198 | 0.68 | EPHX2 (0.60) | EPHX2CYP2C9CYP2J2 | |
| SCHEMBL7399380 | 0.67 | ITGB3 (0.49) | HRH3ITGB3ITGA2B | |
| SCHEMBL7399382 | 0.67 | ITGB3 (0.49) | HRH3ITGB3ITGA2B | |
| SCHEMBL7399643 | 0.67 | HRH1 (0.57) | HRH3ITGB3ITGA2BHRH1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808306-B1 | NEW DERIVATIVES OF PYRIDINE OR PYRIDAZINE, PROCESS FOR PRODUCTION THEREOF AND MEDICAMENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-08-04 | — | — | EP | disclosed |