Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17063922 | 0.82 | CD38 (0.53) | CD38DYRK1ADYRK2DYRK1BLRRK2 | |
| SCHEMBL1872880 | 0.79 | DYRK1A (0.55) | CD38DYRK1ANOTUMDYRK2DYRK1B | |
| SCHEMBL48894 | 0.79 | DYRK1A (0.55) | CD38DYRK1ANOTUMDYRK2DYRK1B | |
| SCHEMBL19219067 | 0.77 | DYRK1A (0.53) | CD38DYRK1ANOTUMDYRK2DYRK1B | |
| SCHEMBL999315 | 0.77 | HDAC8 (0.46) | CD38DYRK1AKMT2ASLC6A3SLC6A2 | |
| SCHEMBL5179594 | 0.77 | ESR1 (0.50) | DYRK1AKMT2ADYRK2DYRK1BRAB9A | |
| Ammonia Solution, Strong SCHEMBL28177501 | 0.77 | DYRK1A (0.53) | CD38DYRK1ADYRK2DYRK1BKDM4E | |
| SCHEMBL7915410 | 0.77 | CD38 (0.49) | CD38DYRK1ASLC6A3SLC6A2DYRK2 | |
| SCHEMBL4541085 | 0.77 | CD38 (0.49) | CD38DYRK1ASLC6A3SLC6A2DYRK2 | |
| SCHEMBL14320606 | 0.77 | APP (0.50) | CD38DYRK1AKMT2ADYRK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109912626-B | Thiazolotriazole superoxide dismutase agonist and preparation method and application thereof | 浙江瑀美生物科技有限公司 | 2021-07-23 | — | — | CN | claimed |
| CN-109912626-A | A kind of thiazole and triazole superoxide dismutase agonist and its preparation method and application | 河南湾流生物科技有限公司 | 2019-06-21 | — | — | CN | claimed |
| CN-109912626-B | Thiazolotriazole superoxide dismutase agonist and preparation method and application thereof | 浙江瑀美生物科技有限公司 | 2021-07-23 | — | — | CN | disclosed |
| US-20200369658-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2020-11-26 | — | — | US | disclosed |
| EP-3197883-B1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2020-03-18 | — | — | EP | disclosed |
| CN-109912626-A | A kind of thiazole and triazole superoxide dismutase agonist and its preparation method and application | 河南湾流生物科技有限公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-109293652-A | A kind of substituted thiazole and application thereof | 四川科伦博泰生物医药股份有限公司 | 2019-02-01 | — | — | CN | disclosed |
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2951167-B1 | NOVEL MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-01-25 | — | — | EP | disclosed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | disclosed |
| CN-103965136-A | Method for preparing N-Methylthiazoline-2-ketone compound | SUZHOU BOFEITE NEW MATERIALS TECHNOLOGY CO LTD | 2014-08-06 | — | — | CN | disclosed |
| US-20130303521-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CHEMICAL WARFARE AGENT-INDUCED INJURIES | HYDRA BIOSCIENCES, INC (US) | 2013-11-14 | — | — | US | disclosed |
| US-20130059869-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | HYDRA BIOSCIENCES, INC. | 2013-03-07 | — | — | US | disclosed |
| WO-2004058760-A1 | THIAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303521-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CHEMICAL WARFARE AGENT-INDUCED INJURIES | ELANE, CASP3, MMP8 | CD38 881/4885DYRK1A 4786/4885KMT2A 2953/4885 |
| US-20200369658-A1 | NOVEL COMPOUNDS | UCHL1, UCHL3, UCHL5 | CD38 906/4885DYRK1A 1587/4885KMT2A 313/4885 |
| US-20130059869-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | TRPA1, TRPV1, TRPV3 | CD38 3038/4885DYRK1A 4523/4885KMT2A 4200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.