Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 3/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313266 | 0.87 | FNTA (0.38) | CTSKKMT2ASCN9AHRH2HRH1 | |
| SCHEMBL8318247 | 0.84 | ADORA1 (0.42) | CTSKKMT2ASCN9AHRH2HRH1 | |
| SCHEMBL8312710 | 0.81 | FAAH (0.35) | CTSKKMT2ASCN9AHRH2HRH1 | |
| SCHEMBL8314426 | 0.78 | GPR119 (0.46) | CYP3A4 | |
| SCHEMBL9389839 | 0.74 | CCKBR (0.38) | KMT2AP2RY12TGM2 | |
| SCHEMBL8522338 | 0.72 | GHSR (0.40) | CTSKKMT2AHRH2HRH1MAPK1 | |
| SCHEMBL8522337 | 0.72 | GHSR (0.40) | CTSKKMT2AHRH2HRH1MAPK1 | |
| SCHEMBL8317004 | 0.71 | CTSK (0.42) | CTSKKMT2AHRH2HRH1MAPK1 | |
| SCHEMBL5444581 | 0.70 | CTSK (0.59) | CTSKKMT2ASCN9AHRH2HRH1 | |
| SCHEMBL8316537 | 0.70 | ITGB3 (0.45) | CTSKKMT2AHRH2HRH1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |
| WO-1994019367-A1 | SPIRO PIPERIDINES AND HOMOLOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-09-01 | — | — | WO | disclosed |