Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324318 | 0.82 | TAAR1 (0.44) | SLC6A2TAAR1SIGMAR1MAOASLC6A4 | |
| SCHEMBL8324358 | 0.81 | TAAR1 (0.43) | SLC6A2TAAR1SIGMAR1MAOASLC6A4 | |
| SCHEMBL8323856 | 0.81 | MAOA (0.49) | SLC6A2TAAR1SIGMAR1MAOASLC6A4 | |
| SCHEMBL8330718 | 0.81 | NFE2L2 (0.49) | SLC6A2TAAR1SIGMAR1MAOASLC6A4 | |
| SCHEMBL8327755 | 0.80 | PNMT (0.41) | PNMTTAAR1SIGMAR1GRIN1GRIN2B | |
| SCHEMBL8324981 | 0.80 | GRIN1 (0.43) | PNMTTAAR1SIGMAR1GRIN1GRIN2B | |
| SCHEMBL8327003 | 0.80 | TRPA1 (0.38) | PNMTSLC6A2TAAR1SIGMAR1MAOA | |
| SCHEMBL8320387 | 0.77 | HTR2A (0.53) | SLC6A2TAAR1SIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL18243444 | 0.75 | CHRM5 (0.52) | PNMTGRIN1GRIN2BALDH1A1CHRM5 | |
| SCHEMBL3335734 | 0.73 | CHRM5 (0.50) | PNMTGRIN1GRIN2BCHRM5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |