Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | HTR2B | P41595 | 3/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326251 | 0.83 | NPC1 (0.59) | HTR2AHTR2BHTR2CCYP3A4SIGMAR1 | |
| SCHEMBL8322396 | 0.82 | HTR2A (0.46) | HTR2AHTR2BHTR2CCYP3A4SIGMAR1 | |
| SCHEMBL8326920 | 0.82 | HTR2A (0.46) | HTR2AHTR2BHTR2CCYP3A4SIGMAR1 | |
| SCHEMBL8330718 | 0.80 | NFE2L2 (0.49) | CYP3A4SIGMAR1CYP1A2CYP2D6SLC6A4 | |
| SCHEMBL8324318 | 0.78 | TAAR1 (0.44) | SIGMAR1CYP2D6TP53SLC6A4NPC1 | |
| SCHEMBL18242242 | 0.77 | NFE2L2 (0.54) | HTR2AHTR2BHTR2CSIGMAR1TSHR | |
| SCHEMBL8319052 | 0.77 | PNMT (0.49) | SIGMAR1TSHRSLC6A4LMNANPC1 | |
| SCHEMBL8324358 | 0.77 | TAAR1 (0.43) | HTR2ASIGMAR1CYP2D6ADRA2CSLC6A4 | |
| SCHEMBL8323856 | 0.77 | MAOA (0.49) | SIGMAR1CYP2D6SLC6A4MAPTNPC1 | |
| SCHEMBL14535006 | 0.74 | HTR2A (0.66) | HTR2AHTR2BHTR2CCYP3A4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |