Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322029 | 0.82 | CYP3A4 (0.40) | TRPA1PPARGPPARASLC6A2SLC6A4 | |
| SCHEMBL8323270 | 0.82 | KDM4E (0.36) | TRPA1PPARGPPARASLC6A2SLC6A4 | |
| SCHEMBL8319052 | 0.80 | PNMT (0.49) | SLC6A2SLC6A4SLC6A3LMNATAAR1 | |
| SCHEMBL8326594 | 0.78 | NFE2L2 (0.44) | TRPA1PPARGPPARASLC6A2SLC6A4 | |
| SCHEMBL8330718 | 0.77 | NFE2L2 (0.49) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8327482 | 0.73 | CYP3A4 (0.42) | TRPA1SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL8327667 | 0.73 | TAAR1 (0.44) | TRPA1PPARGPPARASLC6A2SLC6A4 | |
| SCHEMBL8324318 | 0.72 | TAAR1 (0.44) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8326191 | 0.72 | TRPA1 (0.38) | TRPA1CYP2D6CYP3A4TAAR1CYP2A6 | |
| SCHEMBL8323488 | 0.71 | SLC6A2 (0.41) | TRPA1PPARGPPARASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |