SCHEMBL8324438

SCHEMBL8324438

COc1ccc([CH]C(Cc2ccccc2)N(C)C)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
G6PC1 P35575 1/20 0.48
TRPA1 O75762 1/20 0.46
LTA4H P09960 1/20 0.46
PPARG P37231 1/20 0.46
PPARA Q07869 1/20 0.46
ALDH1A1 P00352 2/20 0.44
TSHR P16473 1/20 0.42
KDM4E B2RXH2 1/20 0.42
MAPT P10636 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
SIGMAR1 Q99720 1/20 0.42
LDHA P00338 1/20 0.41
TRPM8 Q7Z2W7 1/20 0.41
AOC3 Q16853 1/20 0.41
ACHE P22303 2/20 0.40
SLC6A4 P31645 1/20 0.40
EP300 Q09472 1/20 0.40
MMP1 P03956 1/20 0.40
MMP13 P45452 1/20 0.40
BCHE P06276 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8325718 0.83 CYP2C19 (0.40) PPARGPPARAMAPTSIGMAR1SLC6A4
SCHEMBL8323592 0.81 NOS3 (0.40) PPARGPPARAALDH1A1TSHRMAPT
SCHEMBL8323072 0.80 TRPA1 (0.50) G6PC1TRPA1LTA4HPPARGPPARA
SCHEMBL8322987 0.78 NPC1 (0.52) PPARGPPARAALDH1A1TSHRMAPT
SCHEMBL8323399 0.76 LTA4H (0.50) G6PC1TRPA1LTA4HPPARGPPARA
SCHEMBL8324682 0.73 TP53 (0.40) PPARGPPARAALDH1A1SIGMAR1ACHE
SCHEMBL8327755 0.72 PNMT (0.41) ALDH1A1TSHRSIGMAR1AOC3
SCHEMBL8326976 0.72 MAOB (0.45) MAPTSIGMAR1SLC6A4
SCHEMBL8324481 0.72 NFE2L2 (0.45) PPARGPPARASIGMAR1SLC6A4OPRM1
SCHEMBL8323270 0.71 KDM4E (0.36) G6PC1TRPA1PPARGPPARAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0948496-A2 SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE Amgen inc. (US) 1999-10-13 EP disclosed
WO-1998024780-A2 SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE AMGEN INC. (US) 1998-06-11 WO disclosed