Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328991 | 0.85 | ALDH1A1 (0.31) | ALDH1A1LMNA | |
| SCHEMBL8328374 | 0.82 | ACHE (0.42) | — | |
| SCHEMBL8328418 | 0.81 | POLB (0.44) | ALDH1A1LMNA | |
| SCHEMBL8328585 | 0.80 | ALDH1A1 (0.34) | SPHK2SPHK1ALDH1A1NPSR1MAPK1 | |
| SCHEMBL8326577 | 0.78 | ALDH1A1 (0.34) | ALDH1A1NPSR1 | |
| SCHEMBL8326767 | 0.77 | DRD4 (0.47) | LMNA | |
| SCHEMBL8327173 | 0.77 | PRKAA2 (0.42) | ALDH1A1 | |
| SCHEMBL8324755 | 0.77 | SIGMAR1 (0.37) | ALDH1A1MAPK1 | |
| SCHEMBL8322051 | 0.76 | ALDH1A1 (0.42) | ALDH1A1MAPK1 | |
| SCHEMBL8327922 | 0.75 | BCHE (0.35) | ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760368-B1 | PYRIMIDINE DERIVATIVES | NISSHIN FLOUR MILLING CO (JP) | 1999-07-28 | — | — | EP | disclosed |
| US-5736550-A | TREATMENT OF GASTROINTESTINAL TRACT DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-04-07 | — | — | US | disclosed |
| EP-0760368-A1 | NOVEL PYRIMIDINE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |