SCHEMBL8329070

SCHEMBL8329070

O=[N+]([O-])c1ccc(N(Cc2ccc(C(F)(F)F)cc2)c2cncnc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 2/20 0.45
TGM2 P21980 1/20 0.42
CYP19A1 P11511 4/20 0.42
NR1D1 P20393 1/20 0.41
POLB P06746 1/20 0.40
AR P10275 4/20 0.39
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39
IDO1 P14902 1/20 0.38
MAPT P10636 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
MMP2 P08253 1/20 0.37
MMP9 P14780 1/20 0.37
MMP8 P22894 1/20 0.37
MMP13 P45452 1/20 0.37
RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8327952 0.90 CRHBP (0.47) CYP19A1POLBARCRHBPCRHR2
SCHEMBL8323939 0.86 AR (0.49) MMP1CYP19A1NR1D1POLBAR
SCHEMBL8326188 0.84 CYP19A1 (0.55) CYP19A1POLBARCRHBPCRHR2
SCHEMBL8327623 0.84 ALDH1A1 (0.50) MMP1CYP19A1NR1D1POLBAR
SCHEMBL8327171 0.84 CRHBP (0.42) CYP19A1POLBARCRHBPCRHR2
SCHEMBL8323517 0.81 KCNJ1 (0.46) CYP19A1POLBARCRHBPCRHR2
SCHEMBL8324619 0.81 KCNJ1 (0.46) CYP19A1POLBARCRHBPCRHR2
Oxalic Acid SCHEMBL8326149 0.77 AR (0.39) CYP19A1AR
SCHEMBL7226902 0.74 PYCR1 (0.57) MMP1TGM2NR1D1CRHBPCRHR2
SCHEMBL8446097 0.73 CYP19A1 (0.72) MMP1TGM2CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0640595-B1 SUBSTITUTED TERTIARY AMINO COMPOUND OR SALT THEREOF YAMANOUCHI PHARMA CO LTD (JP) 1999-03-24 EP disclosed
CN-1039228-C Novel substituted tert-amino compund YAMANOUCHI PHARMA CO LTD (JP) 1998-07-22 CN disclosed
US-5538976-A ANTICARCINOGENIC AGENTS AND ENZYME INHIBITORS FOR AROMATASE YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1996-07-23 US disclosed
EP-0640595-A1 NOVEL SUBSTITUTED TERTIARY AMINO COMPOUND OR SALT THEREOF YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1995-03-01 EP disclosed
CN-1079962-A New substituted tertiary amine compound and salt thereof YAMANOUCHI PHARMA CO LTD (JP) 1993-12-29 CN disclosed