Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGF1 known ✓ | P05230 | 7/20 | 0.67 |
| ▸ | HPSE | Q9Y251 | 19/20 | 0.67 |
| ▸ | FGF2 | P09038 | 7/20 | 0.67 |
| ▸ | VEGFA | P15692 | 4/20 | 0.67 |
| ▸ | SELL | P14151 | 1/20 | 0.52 |
| ▸ | SELP | P16109 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8334574 | 0.91 | HPSE (0.59) | HPSEFGF1FGF2VEGFA | |
| SCHEMBL8333154 | 0.90 | SELP (0.61) | HPSEFGF1FGF2VEGFASELL | |
| SCHEMBL8333368 | 0.86 | SELP (0.66) | HPSEFGF1FGF2VEGFASELL | |
| SCHEMBL8332237 | 0.81 | FGF1 (0.51) | HPSEFGF1FGF2VEGFASELL | |
| SCHEMBL258089 | 0.81 | SELP (0.57) | HPSEFGF1FGF2VEGFASELL | |
| SCHEMBL8332214 | 0.81 | HPSE (0.63) | HPSEFGF1FGF2VEGFA | |
| SCHEMBL8330536 | 0.77 | SELP (0.79) | VEGFASELLSELP | |
| SCHEMBL8331509 | 0.77 | SELP (0.79) | VEGFASELLSELP | |
| SCHEMBL8331504 | 0.77 | SELP (0.79) | VEGFASELLSELP | |
| SCHEMBL8330539 | 0.77 | SELP (0.79) | VEGFASELLSELP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869460-A | ANTIINFLAMMATORY AGENTS | SANWA KAGUKU KENKYUSHO CO., LTD. (JP) | 1999-02-09 | — | — | US | disclosed |