Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | PRKCG | P05129 | 1/20 | 0.64 |
| ▸ | PRKACA | P17612 | 1/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.64 |
| ▸ | PRKX | P51817 | 1/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.64 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.64 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.64 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.64 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.64 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8352104 | 0.89 | CFD (0.59) | ROCK2ROCK1MAP4K4PRKCGPKN2 | |
| SCHEMBL8350880 | 0.84 | MAPK8 (0.54) | ROCK2ROCK1MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL8351036 | 0.84 | MAPK8 (0.66) | MAPK8MAPK10NPC1LMNAPOLB | |
| SCHEMBL8351194 | 0.80 | MAPK14 (0.55) | ROCK2ROCK1MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL3812691 | 0.79 | ROCK2 (1.00) | ROCK2ROCK1MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL248886 | 0.78 | ROCK2 (0.64) | ROCK2ROCK1MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL14348407 | 0.78 | CAMK2D (0.72) | ROCK2ROCK1MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL539059 | 0.77 | EPHX2 (0.84) | ROCK2ROCK1MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL8350912 | 0.77 | CSNK1D (0.53) | ROCK1MAP4K4PRKCGPKN2MAP4K5 | |
| SCHEMBL8350684 | 0.77 | MAPK8 (0.55) | MAPK8MAPK10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |