Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136763 | 0.78 | GLA (0.34) | POLBGLANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7077670 | 0.77 | LMNA (0.44) | NPC1RAB9ASMN1; SMN2MAPTHPGD | |
| SCHEMBL7074301 | 0.77 | AOC3 (0.39) | POLBGLANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7074971 | 0.74 | GABBR2 (0.34) | SMN1; SMN2TP53MAPTMAPK1 | |
| SCHEMBL7080823 | 0.74 | GABBR2 (0.49) | POLBNPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL8909238 | 0.73 | GABBR2 (0.56) | MAPTKMT2AMEN1 | |
| SCHEMBL7135413 | 0.73 | GRM4 (0.53) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL7078041 | 0.72 | RORC (0.47) | LMNA | |
| SCHEMBL7077928 | 0.72 | NPY1R (0.39) | NPC1RAB9AMAPTHPGDKMT2A | |
| SCHEMBL8357377 | 0.71 | ALDH1A1 (0.44) | POLBNPC1RAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |