Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | ADH1C | P00326 | 1/20 | 0.30 |
| ▸ | ADH1A | P07327 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8375152 | 0.89 | ADH1C (0.34) | ADH1CADH1A | |
| SCHEMBL8375879 | 0.76 | ITGB1 (0.32) | ADH1CADH1A | |
| Dimethylcarbate SCHEMBL8436277 | 0.64 | ADH1C (0.33) | ADH1CADH1A | |
| Maleic Acid SCHEMBL8572325 | 0.62 | TRPM8 (0.36) | MAPK1 | |
| Maleic Acid SCHEMBL9681627 | 0.62 | MEN1 (0.32) | MAPK1 | |
| SCHEMBL8374737 | 0.56 | RAB9A (0.34) | MAPK1 | |
| SCHEMBL21891518 | 0.54 | TRPM8 (0.50) | ADH1CADH1A | |
| SCHEMBL30764069 | 0.54 | TRPM8 (0.50) | ADH1CADH1A | |
| Cyclohexane SCHEMBL5597823 | 0.53 | ALDH1A1 (0.41) | — | |
| Fumaric Acid SCHEMBL8666586 | 0.53 | HTT (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869480-A | ALLEVIATING MEMORY DYSFUNCTION CHARACTERIZED BY CHOLINERGIC DEFICIT | HOECHST MARION ROUSSEL INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5866565-A | ALZHEIMER'S DISORDERS | HOECHST MARION ROUSSEL INC. (US) | 1999-02-02 | — | — | US | disclosed |