Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 9/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | DHPS | P49366 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 8/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8398581 | 0.89 | NPBWR1 (0.35) | EDNRANPBWR1MCHR1DHPSEDNRB | |
| SCHEMBL8398732 | 0.88 | EDNRA (0.42) | LMNAEDNRADHPSEDNRB | |
| SCHEMBL7589754 | 0.85 | EDNRA (0.47) | EDNRAEDNRB | |
| SCHEMBL8398843 | 0.77 | DHPS (0.41) | EDNRADHPSEDNRBADORA3ADORA2A | |
| SCHEMBL7591710 | 0.76 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL8635722 | 0.76 | DHPS (0.35) | EDNRANPBWR1MCHR1DHPSEDNRB | |
| SCHEMBL7589698 | 0.76 | ALDH1A1 (0.47) | DHPSMAPTADORA3ADORA2AADORA1 | |
| SCHEMBL7580836 | 0.74 | EDNRA (0.44) | EDNRAEDNRB | |
| SCHEMBL8637899 | 0.73 | DHPS (0.43) | EDNRADHPSEDNRB | |
| SCHEMBL7991567 | 0.71 | EDNRA (0.62) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856484-A | Sulfonylaminopyrimidine carboxylic acid derivatives having endothelin inhibiting activity | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |