Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 10/20 | 0.35 |
| ▸ | CTSS | P25774 | 10/20 | 0.35 |
| ▸ | CTSB | P07858 | 8/20 | 0.35 |
| ▸ | CTSK | P43235 | 6/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8422387 | 0.87 | CTSL (0.35) | ALDH1A1SMN1; SMN2CTSLCTSSCTSB | |
| SCHEMBL8526941 | 0.83 | PPID (0.39) | ALDH1A1SMN1; SMN2RAB9ACA1CA2 | |
| SCHEMBL8528385 | 0.74 | THRA (0.36) | ALDH1A1SMN1; SMN2RAB9AKMT2ATACR1 | |
| SCHEMBL1428501 | 0.71 | TSHR (0.48) | ALDH1A1SMN1; SMN2RAB9ACA1CA2 | |
| SCHEMBL27611926 | 0.69 | TSHR (0.43) | ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL21652695 | 0.65 | MGAM (0.62) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8978333 | 0.65 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2CTSLCTSSCTSB | |
| SCHEMBL27630941 | 0.65 | TPSAB1 (0.44) | ALDH1A1SMN1; SMN2CA1CA2MEN1 | |
| SCHEMBL27611924 | 0.65 | KDM4E (0.39) | ALDH1A1SMN1; SMN2CA1CA2MEN1 | |
| SCHEMBL2781111 | 0.65 | PPIB (0.40) | ALDH1A1SMN1; SMN2CA1CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874472-A | Aminoacid derivatives as no synthase inhibitors | GLAXO WELLCOME INC. (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0705257-B1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | WELLCOME FOUND (GB) | 1998-03-11 | — | — | EP | disclosed |
| EP-0705257-A1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000505-A1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-01-05 | — | — | WO | disclosed |