Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8526941 | 0.85 | PPID (0.39) | HTTNPSR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2780510 | 0.83 | ALDH1A1 (0.42) | THRATHRBPOLBTACR1ALDH1A1 | |
| SCHEMBL8422387 | 0.82 | CTSL (0.35) | KMT2ATACR1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14416816 | 0.77 | THRA (0.44) | THRATHRBNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3911621 | 0.74 | ALDH1A1 (0.45) | THRATHRBPOLBTACR1ALDH1A1 | |
| SCHEMBL8422211 | 0.74 | ALDH1A1 (0.38) | KMT2ATACR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27615700 | 0.73 | SLC15A1 (0.45) | THRATHRBPOLBTACR1ALDH1A1 | |
| SCHEMBL1428501 | 0.73 | TSHR (0.48) | KMT2AHTTNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21385079 | 0.72 | THRA (0.45) | THRATHRBALDH1A1GLAKDM4E | |
| SCHEMBL11830714 | 0.72 | FOLH1 (0.48) | KMT2ASMN1; SMN2SLC7A5PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705257-B1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | WELLCOME FOUND (GB) | 1998-03-11 | — | — | EP | disclosed |
| EP-0705257-A1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000505-A1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-01-05 | — | — | WO | disclosed |