Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASE1 | P07998 | 1/20 | 0.37 |
| ▸ | TK1 | P04183 | 6/20 | 0.36 |
| ▸ | TK2 | O00142 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5668664 | 0.83 | TK1 (0.39) | RNASE1TK1TK2HPGDTYMP | |
| SCHEMBL9396543 | 0.76 | RNASE1 (0.39) | RNASE1TK1TK2 | |
| SCHEMBL6851558 | 0.73 | TK1 (0.34) | TK1TK2 | |
| SCHEMBL8539644 | 0.73 | LMNA (0.37) | TK2 | |
| SCHEMBL9755149 | 0.71 | RNASE1 (0.39) | RNASE1TK1TK2HPGDMAPK1 | |
| SCHEMBL9064864 | 0.70 | RNASE1 (0.38) | RNASE1TK1TK2HPGDMAPK1 | |
| SCHEMBL9062998 | 0.70 | RNASE1 (0.40) | RNASE1TK1TK2HPGD | |
| SCHEMBL9029503 | 0.69 | P2RY2 (0.41) | — | |
| SCHEMBL9030188 | 0.69 | P2RY2 (0.41) | — | |
| SCHEMBL4949384 | 0.69 | TK2 (0.39) | RNASE1TK1TK2TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965722-A | OLIGONUCLEOTIDE WITH METHYLENE(METHYLIMINO) LINKAGES ALTERNATING WITH PHOSPHOROTHIOATE OR PHOSPHODIESTER LINKAGES; WITH INCREASED NUCLEASE RESISTANCE, STABILITY, AFFINITY FOR MESSENGER RNA; ANTICARCINOGENIC/ANTIARRHYTHMIA AGENTS | ISIS PHARMACEUTICALS, INC. (US) | 1999-10-12 | — | — | US | disclosed |