Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695507 | 0.97 | TSHR (0.36) | TSHRALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL7892695 | 0.95 | TSHR (0.34) | TSHRALDH1A1CYP3A4HSD17B10 | |
| Sulfuric Acid SCHEMBL8005689 | 0.89 | TSHR (0.33) | TSHR | |
| SCHEMBL7537680 | 0.83 | — | — | |
| SCHEMBL8991711 | 0.83 | — | — | |
| SCHEMBL11801224 | 0.83 | MEN1 (0.33) | — | |
| SCHEMBL5169996 | 0.75 | LMNA (0.36) | TSHRALDH1A1 | |
| Water SCHEMBL8741426 | 0.75 | METAP2 (0.34) | — | |
| SCHEMBL779294 | 0.72 | — | — | |
| SCHEMBL12039846 | 0.72 | ALDH1A1 (0.33) | TSHRALDH1A1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5900356-A | ALL PHOTOSENSITIVE LAYERS OF SAID THREE COLOR SENSITIVE EMULSION LAYER UNITS CONTAIN PHOTOSENSITIVE TABULAR SILVER HALOIODIDE GRAINS HAVING AN ASPECT RATIO OF FROM TWO TO 100, SAID GRAINS EACH HAVING A PROJECTION AT AT LEAST ONE VERTEX | FUJI PHOTO FILM CO., LTD. (JP) | 1999-05-04 | — | — | US | disclosed |
| US-5691125-A | CYAN DYE-FORMING COUPLER, STORAGE STABLE | FUJI PHOTO FILM CO., LTD. (JP) | 1997-11-25 | — | — | US | disclosed |
| US-5578436-A | EXCELLENT SENSITIVITY/GRAININESS RATIO AND COLOR REPRODUCTION | FUJI PHOTO FILM CO., LTD. (JP) | 1996-11-26 | — | — | US | disclosed |
| US-5578441-A | Silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1996-11-26 | — | — | US | disclosed |
| US-5460929-A | Silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5380638-A | Colorfast, naphthol substituted with amidophenylamide group | FUJI PHOTO FILM CO., LTD. (JP) | 1995-01-10 | — | — | US | disclosed |