Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 4/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8668070 | 0.95 | MEN1 (0.35) | TSHRMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL8503791 | 0.91 | TSHR (0.37) | TSHRMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL8675063 | 0.86 | L3MBTL1 (0.42) | TSHRMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL8480927 | 0.85 | NPSR1 (0.41) | TSHRMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL8485591 | 0.84 | NPY1R (0.41) | TSHRMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL8479245 | 0.80 | SCN1A (0.39) | MEN1KMT2A | |
| SCHEMBL8487923 | 0.78 | SCN1A (0.38) | MEN1KMT2A | |
| SCHEMBL8480408 | 0.78 | TMEM97 (0.38) | TSHRMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL8485124 | 0.78 | OPRK1 (0.33) | DRD2HTR1AOPRK1 | |
| SCHEMBL8669685 | 0.78 | NPSR1 (0.42) | NPSR1DRD2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739135-A | PREVENTING OR TREATING ATHEROSCLEROSIS, PANCREATITIS SECONDARY TO HYPERTRIGLYCERIDEMIA, HYPERGLYCEMIA, OBESITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-14 | — | — | US | claimed |
| US-5883099-A | TREATMENT OF ATHERSCLEROSIS, PANCREATITIS OBESITY OR HYPERGLYCEMIA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-16 | — | — | US | disclosed |
| US-5739135-A | PREVENTING OR TREATING ATHEROSCLEROSIS, PANCREATITIS SECONDARY TO HYPERTRIGLYCERIDEMIA, HYPERGLYCEMIA, OBESITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-14 | — | — | US | disclosed |