Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8675063 | 0.90 | L3MBTL1 (0.42) | HTR2AL3MBTL1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL8480927 | 0.85 | NPSR1 (0.41) | HTR2AL3MBTL1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8668070 | 0.82 | MEN1 (0.35) | HTR2ASMN1; SMN2NPSR1MEN1TSHR | |
| SCHEMBL8714742 | 0.81 | NPSR1 (0.39) | HTR2AALDH1A1NPSR1GAAHPGD | |
| SCHEMBL8503791 | 0.80 | TSHR (0.37) | HTR2ASMN1; SMN2NPSR1MEN1TSHR | |
| SCHEMBL8485120 | 0.78 | TSHR (0.36) | HTR2ASMN1; SMN2NPSR1MEN1TSHR | |
| SCHEMBL8669685 | 0.77 | NPSR1 (0.42) | NPSR1 | |
| SCHEMBL8480413 | 0.77 | TMEM97 (0.35) | TMEM97HTR2ASIGMAR1HTR2BL3MBTL1 | |
| SCHEMBL8667850 | 0.76 | L3MBTL1 (0.42) | HTR2AHTR2BL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8593677 | 0.75 | ALDH1A1 (0.36) | HTR2AL3MBTL1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883099-A | TREATMENT OF ATHERSCLEROSIS, PANCREATITIS OBESITY OR HYPERGLYCEMIA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-16 | — | — | US | disclosed |
| US-5739135-A | PREVENTING OR TREATING ATHEROSCLEROSIS, PANCREATITIS SECONDARY TO HYPERTRIGLYCERIDEMIA, HYPERGLYCEMIA, OBESITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-14 | — | — | US | disclosed |