Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PER2 | O15055 | 5/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | CRY1 | Q16526 | 4/20 | 0.32 |
| ▸ | CRY2 | Q49AN0 | 4/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486390 | 0.96 | S1PR1 (0.36) | PER2S1PR1CRY1CRY2SIGMAR1 | |
| SCHEMBL8489654 | 0.96 | S1PR1 (0.36) | PER2S1PR1CRY1CRY2SIGMAR1 | |
| SCHEMBL8488046 | 0.87 | PER2 (0.42) | PER2CRY1CRY2 | |
| SCHEMBL8489932 | 0.84 | PER2 (0.42) | PER2S1PR1CRY1CRY2ALDH1A1 | |
| SCHEMBL8488408 | 0.83 | PER2 (0.51) | PER2CRY1CRY2 | |
| SCHEMBL8484814 | 0.81 | CRY1 (0.49) | PER2CRY1CRY2ALDH1A1 | |
| SCHEMBL8485649 | 0.80 | PER2 (0.40) | PER2S1PR1CRY1CRY2ALDH1A1 | |
| SCHEMBL8490612 | 0.80 | PER2 (0.40) | PER2S1PR1CRY1CRY2ALDH1A1 | |
| SCHEMBL8486007 | 0.79 | LMNA (0.44) | PER2CRY1CRY2ALDH1A1 | |
| SCHEMBL8488093 | 0.73 | PER2 (0.33) | PER2CRY1CRY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919431-A | 1,4,7,10-tetraazacyclododecane derivatives, their use, pharmaceutical agents containing these compounds and process for their production | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-07-06 | — | — | US | disclosed |