Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | PER2 | O15055 | 1/20 | 0.41 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.41 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.41 |
| ▸ | BMP1 | P13497 | 7/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8488408 | 0.90 | PER2 (0.51) | LMNABACE1PER2CRY1CRY2 | |
| SCHEMBL8488572 | 0.88 | BACE1 (0.48) | LMNAALDH1A1BACE1PER2CRY1 | |
| SCHEMBL8488046 | 0.81 | PER2 (0.42) | LMNAPER2CRY1CRY2SMN1; SMN2 | |
| SCHEMBL8484814 | 0.80 | CRY1 (0.49) | LMNAALDH1A1BACE1PER2CRY1 | |
| SCHEMBL8488567 | 0.79 | PER2 (0.34) | ALDH1A1PER2CRY1CRY2 | |
| SCHEMBL8489654 | 0.78 | S1PR1 (0.36) | PER2CRY1CRY2 | |
| SCHEMBL8487896 | 0.77 | BACE1 (0.44) | LMNAALDH1A1BACE1PER2CRY1 | |
| SCHEMBL8488579 | 0.71 | LMNA (0.39) | LMNAALDH1A1BACE1SMN1; SMN2CHRM5 | |
| SCHEMBL8489557 | 0.68 | PER2 (0.55) | ALDH1A1BACE1PER2CRY1CRY2 | |
| SCHEMBL8488753 | 0.67 | PER2 (0.51) | ALDH1A1BACE1PER2CRY1CRY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919431-A | 1,4,7,10-tetraazacyclododecane derivatives, their use, pharmaceutical agents containing these compounds and process for their production | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-07-06 | — | — | US | disclosed |