Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Azelaic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.63 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.53 |
| ▸ | FABP3 | P05413 | 7/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28402678 | 1.00 | CA1 (0.63) | CA1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL6053545 | 1.00 | CA1 (0.63) | CA1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL30930281 | 1.00 | CA1 (0.63) | CA1HDAC3HDAC1HDAC2HDAC8 | |
| Pimelic Acid SCHEMBL6756717 | 1.00 | CA1 (0.63) | CA1HDAC3HDAC1HDAC2HDAC8 | |
| Sebacic Acid SCHEMBL306520 | 1.00 | CA1 (0.63) | CA1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL20577558 | 1.00 | CA1 (0.63) | CA1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL11046980 | 1.00 | CA1 (0.63) | CA1HDAC3HDAC1HDAC2HDAC8 | |
| Octanedioate SCHEMBL188028 | 1.00 | CA1 (0.63) | CA1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL8325989 | 1.00 | CA1 (0.63) | CA1HDAC3HDAC1HDAC2HDAC8 | |
| Sebacic Acid SCHEMBL29696252 | 1.00 | CA1 (0.63) | CA1HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 197 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119488469-A | Anti-drop and anti-dandruff composition and preparation method thereof | 广东领秀首美生物科技有限公司 | 2025-02-21 | — | — | CN | claimed |
| CN-118141762-B | Foam-type pharmaceutical agent and foam composition for topical application | 北京罗诺强施医药技术研发中心有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-118141762-A | Foam-type pharmaceutical agent and foam composition for topical application | 北京罗诺强施医药技术研发中心有限公司 | 2024-06-07 | — | — | CN | claimed |
| CN-117653570-A | Composition with oil control and fluffiness effects and preparation method and application thereof | 珠海博御中医药研究有限公司 | 2024-03-08 | — | — | CN | claimed |
| CN-116585245-B | Shampoo containing ginger root extract and preparation method thereof | 珠海博御中医药研究有限公司 | 2024-02-09 | — | — | CN | claimed |
| CN-116585245-A | Shampoo containing ginger root extract and preparation method thereof | 珠海博御中医药研究有限公司 | 2023-08-15 | — | — | CN | claimed |
| CN-112080251-B | Wafer grinding fluid and preparation method thereof | 威科赛乐微电子股份有限公司 | 2022-06-10 | — | — | CN | claimed |
| CN-112795418-A | Tetra-urea lubricating grease composition prepared from aromatic diamine and preparation method thereof | 青岛中科润美润滑材料技术有限公司 | 2021-05-14 | — | — | CN | claimed |
| CN-112375607-A | Tetraurea lubricating grease composition and preparation method thereof | 青岛中科润美润滑材料技术有限公司 | 2021-02-19 | — | — | CN | claimed |
| CN-110797208-B | Preparation method and application of electrode material | 南京大学 | 2020-12-22 | — | — | CN | claimed |
| US-20160029622-A1 | Plant Pathogen Resistance | THE UNIVERSITY OF CHICAGO | 2016-02-04 | — | — | US | claimed |
| EP-2965625-A1 | PLANT PATHOGEN RESISTANCE | The University of Chicago (US) | 2016-01-13 | — | — | EP | claimed |
| US-9161533-B2 | Plant pathogen resistance | THE UNIVERSITY OF CHICAGO (US) | 2015-10-20 | — | — | US | claimed |
| EP-2187736-B1 | PLANT PATHOGEN RESISTANCE | UNIV CHICAGO (US) | 2015-07-29 | — | — | EP | claimed |
| US-20130130907-A1 | PLANT PATHOGEN RESISTANCE | UT-Batlelle, LLC (US) | 2013-05-23 | — | — | US | claimed |
| US-8318786-B2 | Plant pathogen resistance | THE UNIVERSITY OF CHICAGO (US) | 2012-11-27 | — | — | US | claimed |
| JP-2010536785-A | — | — | 2010-12-02 | — | — | JP | claimed |
| EP-2187736-A2 | PLANT PATHOGEN RESISTANCE | The University of Chicago (US) | 2010-05-26 | — | — | EP | claimed |
| WO-2009055126-A2 | PLANT PATHOGEN RESISTANCE | THE UNIVERSITY OF CHICAGO (US) | 2009-04-30 | — | — | WO | claimed |
| US-20090048312-A1 | PLANT PATHOGEN RESISTANCE | THE UNIVERSITY OF CHICAGO (US) | 2009-02-19 | — | — | US | claimed |