Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.33 |
| ▸ | CDK1 | P06493 | 4/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CCND1 | P24385 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539127 | 0.83 | CDK2 (0.35) | CDK2ALDH1A1AURKAAURKBCA1 | |
| SCHEMBL8538654 | 0.81 | PRMT5 (0.37) | PARP1MEN1ALDH1A1KMT2ATTK | |
| SCHEMBL8535835 | 0.76 | HSD17B10 (0.39) | MAPK1GAACA1CA2 | |
| SCHEMBL8537910 | 0.76 | NCF1 (0.34) | CDK1CDK2MEN1KMT2A | |
| SCHEMBL8539150 | 0.74 | ADRA2A (0.39) | MEN1ALDH1A1KMT2ACA1CA2 | |
| SCHEMBL8535592 | 0.73 | PTGS1 (0.40) | ALDH1A1CA1CA2PTGS1PTGS2 | |
| SCHEMBL27340761 | 0.73 | NCF1 (0.34) | CDK1CDK2MEN1KMT2A | |
| SCHEMBL8541078 | 0.72 | ALDH1A1 (0.44) | EIF2AK2KDRMEN1ALDH1A1KMT2A | |
| SCHEMBL8540497 | 0.71 | DCPS (0.41) | RIPK1 | |
| SCHEMBL13106207 | 0.69 | HSP90AB1 (0.39) | PARP1HSP90AB1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657450-B1 | INDAZOLESULFONYLUREA DERIVATIVE, USE THEREOF, AND INTERMEDIATE FOR PRODUCTION THEREOF | KUMIAI CHEMICAL INDUSTRY CO (JP) | 1998-09-09 | — | — | EP | disclosed |
| US-5763616-A | HERBICIDES | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| US-5670452-A | PREEMERGENCE HERBICIDES | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| US-5534481-A | Indazolesulfonylurea derivative, its use and intermediate for its production | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-07-09 | — | — | US | disclosed |
| EP-0657450-A1 | INDAZOLESULFONYLUREA DERIVATIVE, USE THEREOF, AND INTERMEDIATE FOR PRODUCTION THEREOF | KumaiI Chemical Industry Co., Ltd. (JP) | 1995-06-14 | — | — | EP | disclosed |