Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | TP53 | P04637 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549838 | 0.82 | ALDH1A1 (0.47) | RAB9ASMN1; SMN2TP53NPC1PKM | |
| SCHEMBL7143949 | 0.80 | HTR1F (0.66) | RAB9ASMN1; SMN2TP53NPC1PKM | |
| SCHEMBL8552436 | 0.80 | KMT2A (0.49) | RAB9ASMN1; SMN2TP53NPC1PKM | |
| SCHEMBL8549636 | 0.80 | HTR1F (0.51) | RAB9ASMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL8552580 | 0.80 | HTR1F (0.65) | RAB9ASMN1; SMN2TP53NPC1MAPT | |
| SCHEMBL8547488 | 0.80 | HTR1F (0.53) | RAB9ASMN1; SMN2NPC1MAPTHSD17B10 | |
| SCHEMBL8549211 | 0.78 | HTR1F (0.49) | RAB9ANPC1MAPTALDH1A1KDM4E | |
| SCHEMBL8552089 | 0.78 | HTR1F (0.52) | RAB9ASMN1; SMN2TP53NPC1MAPT | |
| SCHEMBL8692074 | 0.78 | HPGD (0.45) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL8551309 | 0.78 | RAB9A (0.48) | RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |