Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | HTR1F | P30939 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549838 | 0.85 | ALDH1A1 (0.47) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8546895 | 0.80 | MEN1 (0.43) | RAB9AMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL8692074 | 0.80 | HPGD (0.45) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8549636 | 0.78 | HTR1F (0.51) | RAB9AMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL8552580 | 0.78 | HTR1F (0.65) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8547488 | 0.78 | HTR1F (0.53) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7144819 | 0.78 | HTR1F (0.64) | LMNAKDM4EALDH1A1GBA1MCHR1 | |
| SCHEMBL8553305 | 0.78 | SMN1; SMN2 (0.42) | RAB9AGAASMN1; SMN2NPC1KDM4E | |
| SCHEMBL8548295 | 0.78 | RAB9A (0.51) | RAB9AMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL8552436 | 0.77 | KMT2A (0.49) | RAB9AMEN1KMT2AGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |