Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552472 | 0.89 | MAPT (0.40) | ALDH1A1MAPTSMN1; SMN2RAD52 | |
| SCHEMBL8550687 | 0.77 | DRD4 (0.48) | POLBTDP1ALDH1A1MAPTTSHR | |
| SCHEMBL8551580 | 0.76 | ALDH1A1 (0.38) | ALDH1A1MAPTSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL8549102 | 0.73 | SMN1; SMN2 (0.39) | ALDH1A1MAPTSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL8550140 | 0.73 | NAMPT (0.45) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8549327 | 0.70 | DRD2 (0.39) | POLBTDP1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8549471 | 0.70 | DRD4 (0.48) | MAPT | |
| SCHEMBL8551575 | 0.70 | DRD4 (0.48) | ALDH1A1 | |
| SCHEMBL8553551 | 0.70 | DRD4 (0.48) | — | |
| SCHEMBL8550252 | 0.69 | DRD4 (0.59) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | claimed |
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |