Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549068 | 0.89 | POLB (0.39) | MAPTRAD52SMN1; SMN2ALDH1A1 | |
| SCHEMBL8549843 | 0.79 | DRD4 (0.46) | MAPTLMNAHTR1AAKR1C3RORC | |
| SCHEMBL8551580 | 0.74 | ALDH1A1 (0.38) | MAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8554330 | 0.73 | CD274 (0.59) | HTR1A | |
| SCHEMBL8550140 | 0.72 | NAMPT (0.45) | MAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8549102 | 0.71 | SMN1; SMN2 (0.39) | MAPTLMNARAD52SMN1; SMN2ALDH1A1 | |
| SCHEMBL8550849 | 0.70 | DRD4 (0.46) | MAPTLMNAHTR1A | |
| SCHEMBL8549507 | 0.70 | HTR7 (0.45) | MAPTGAA | |
| SCHEMBL8549327 | 0.69 | DRD2 (0.39) | MAPTLMNAHTR1AAKR1C3SMN1; SMN2 | |
| SCHEMBL8550263 | 0.68 | DRD4 (0.48) | HTR1ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | claimed |