Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546655 | 0.85 | MAPK1 (0.42) | HSD11B1SMN1; SMN2CYP1A2NPC1RAB9A | |
| SCHEMBL8552464 | 0.85 | ADORA2A (0.37) | HSD11B1SMN1; SMN2SMOCYP1A2ELANE | |
| SCHEMBL8548393 | 0.81 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL8549262 | 0.81 | ALDH1A1 (0.41) | SMN1; SMN2CYP1A2HPGDKMT2AALDH1A1 | |
| SCHEMBL8549276 | 0.78 | PLAU (0.43) | HSD11B1SMN1; SMN2SMOKMT2AGAA | |
| SCHEMBL8549269 | 0.76 | HSD11B1 (0.34) | HSD11B1SMN1; SMN2SMOGPR84MAOB | |
| SCHEMBL8551565 | 0.76 | KMT2A (0.42) | SMN1; SMN2SMOCYP1A2NPC1RAB9A | |
| SCHEMBL8551877 | 0.74 | ESR1 (0.37) | SMN1; SMN2SMOCYP1A2HPGDGPR84 | |
| SCHEMBL8552195 | 0.74 | AR (0.42) | HSD11B1SMN1; SMN2CYP1A2ELANENPC1 | |
| SCHEMBL28934596 | 0.72 | L3MBTL1 (0.37) | SMN1; SMN2CYP1A2NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |