Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055826 | 0.90 | MEN1 (0.48) | MEN1KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL7055006 | 0.87 | MEN1 (0.46) | MEN1KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL9630466 | 0.84 | MEN1 (0.43) | MEN1KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL9186152 | 0.83 | TSHR (0.34) | MEN1KMT2ATSHRSLC1A2SMN1; SMN2 | |
| SCHEMBL9432674 | 0.82 | TSHR (0.42) | MEN1KMT2AALDH1A1TSHRTDP1 | |
| SCHEMBL20522498 | 0.81 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL9594621 | 0.81 | TDP1 (0.47) | MEN1KMT2AALDH1A1LMNATSHR | |
| SCHEMBL15455352 | 0.80 | TSHR (0.41) | MEN1KMT2AALDH1A1TSHRTDP1 | |
| SCHEMBL3010250 | 0.78 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL4441158 | 0.78 | SLC1A2 (0.47) | MEN1KMT2AALDH1A1TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103755622-A | Method for synthesizing 4,5,6-7-D4indole-3-acetic acid | UNIV EAST CHINA SCIENCE & TECH | 2014-04-30 | — | — | CN | disclosed |
| US-8563714-B2 | Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-10-22 | — | — | US | disclosed |
| EP-2350061-B1 | 2,3-DISUBSTITUTED PIPERIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | disclosed |
| EP-2350061-B1 | 2,3-DISUBSTITUTED PIPERIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | disclosed |
| EP-2432760-B1 | BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-07-17 | — | — | EP | disclosed |
| US-8357700-B2 | 2,3-disubstituted piperidine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-01-22 | — | — | US | disclosed |
| US-8357700-B2 | 2,3-disubstituted piperidine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-01-22 | — | — | US | disclosed |
| US-8357700-B2 | 2,3-disubstituted piperidine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-01-22 | — | — | US | disclosed |
| US-20120115841-A1 | BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-05-10 | — | — | US | disclosed |
| EP-2432760-A1 | BRIDGED SPIRO [2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-28 | — | — | EP | disclosed |
| US-20110263643-A1 | 2,3-Disubstituted Piperidine Orexin Receptor Antagonists | MERCK SHARP & DOHME LLC | 2011-10-27 | — | — | US | disclosed |
| US-20110263643-A1 | 2,3-Disubstituted Piperidine Orexin Receptor Antagonists | MERCK SHARP & DOHME LLC | 2011-10-27 | — | — | US | disclosed |
| US-20110263643-A1 | 2,3-Disubstituted Piperidine Orexin Receptor Antagonists | MERCK SHARP & DOHME LLC | 2011-10-27 | — | — | US | disclosed |
| WO-2010134014-A1 | BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-25 | — | — | WO | disclosed |
| WO-2010048016-A1 | 2,3-DISUBSTITUTED PIPERIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-04-29 | — | — | WO | disclosed |
| US-6951866-B2 | Bicyclic pyrimidine compounds and therapeutic use thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-10-04 | — | — | US | disclosed |
| EP-1110951-B1 | PYRIMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-20030105323-A1 | Pyrimidine derivative | SUMITOMO PHARMACEUTICALS COMPANY LIMITED | 2003-06-05 | — | — | US | disclosed |
| US-6458798-B1 | HAS AN INHIBITORY ACTIVITY OF PRODUCTION OF TH2 TYPE CYTOKINES SUCH AS IL-4, IL-5, ETC., AND IS USEFUL AS AN THERAPEUTIC AGENT FOR ALLERGIC DISEASES, AUTOIMMUNE DISEASES SUCH AS SYSTEMIC LUPUS ERYTHEMATHOSUS, ETC., AND ACQUIRED | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-10-01 | — | — | US | disclosed |
| EP-1110951-A1 | PYRIMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115841-A1 | BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | FPR1, FPR2, FPR3 | MEN1 4630/4885KMT2A 3813/4885ALDH1A1 1293/4885 |
| US-20110263643-A1 | 2,3-Disubstituted Piperidine Orexin Receptor Antagonists | HCRTR2, HCRTR1, CRHR2 | MEN1 2214/4885KMT2A 714/4885ALDH1A1 2194/4885 |
| US-20030105323-A1 | Pyrimidine derivative | IL5, IL4, IL15 | MEN1 3390/4885KMT2A 2905/4885ALDH1A1 1331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.