Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551148 | 0.94 | ENPP3 (0.38) | LMNASMN1; SMN2NR1H2NR1H3MAPT | |
| SCHEMBL8552079 | 0.91 | SMN1; SMN2 (0.34) | LMNASMN1; SMN2MAPTCA9KDR | |
| SCHEMBL8550319 | 0.91 | KDM4E (0.37) | SMN1; SMN2NR1H2NR1H3MAPTCA9 | |
| SCHEMBL8547661 | 0.90 | ALDH1A1 (0.43) | SMN1; SMN2MAPTCA9KDRENPP3 | |
| Hydrochloric Acid SCHEMBL8548628 | 0.89 | KDM4E (0.37) | SMN1; SMN2NR1H2NR1H3MAPTCA9 | |
| SCHEMBL8553998 | 0.86 | KDR (0.37) | LMNASMN1; SMN2MAPTCA9KDR | |
| SCHEMBL8546406 | 0.83 | SMN1; SMN2 (0.36) | LMNASMN1; SMN2MAPTKDRENPP3 | |
| SCHEMBL8553715 | 0.76 | NR1H2 (0.38) | LMNASMN1; SMN2NR1H2NR1H3MAPT | |
| SCHEMBL8552267 | 0.76 | HSD11B1 (0.38) | SMN1; SMN2KDRKDM4E | |
| SCHEMBL8551133 | 0.75 | NR1H2 (0.42) | NR1H2NR1H3MAPTNR1I2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |