Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 8/20 | 0.41 |
| ▸ | FEN1 | P39748 | 8/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559922 | 0.96 | ALOX5AP (0.41) | ALOX5APFEN1PTGES2PTGS1PTGS2 | |
| SCHEMBL8555192 | 0.92 | POLB (0.37) | ALOX5APFEN1PTGES2PTGS1PTGS2 | |
| SCHEMBL8560516 | 0.90 | FAAH (0.36) | ALOX5APFEN1ADORA2ACA12CA1 | |
| SCHEMBL8559362 | 0.90 | ALOX5AP (0.40) | ALOX5APFEN1PTGS1PTGS2FAAH | |
| SCHEMBL8559713 | 0.90 | FABP1 (0.38) | ALOX5APFEN1PTGS1PTGS2LTB4R | |
| SCHEMBL8561143 | 0.90 | POLB (0.37) | ALOX5APFEN1PTGES2PTGS1PTGS2 | |
| SCHEMBL8556320 | 0.88 | GRM2 (0.42) | ALOX5APFEN1POLBCA12CA1 | |
| SCHEMBL8558356 | 0.88 | FABP1 (0.38) | ALOX5APFEN1PTGES2PTGS1PTGS2 | |
| SCHEMBL8560978 | 0.87 | CDK9 (0.42) | CA12CA1CA2CA9 | |
| SCHEMBL8561129 | 0.86 | PTGS2 (0.44) | PTGS1PTGS2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |