Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871407 | 0.91 | KMT2A (0.48) | SLC6A4ACHEHTR1AHTR1DHTR1B | |
| SCHEMBL8871654 | 0.82 | MPO (0.59) | SLC6A4HTR1ACDK4CCND1MPO | |
| SCHEMBL8870466 | 0.80 | HTR1A (0.63) | SLC6A4HTR1AMPO | |
| SCHEMBL8870996 | 0.80 | TSHR (0.47) | TSHRPTGDR2SLC6A4TACR1TACR3 | |
| SCHEMBL8557474 | 0.79 | HSD11B1 (0.48) | TSHRPTGDR2SLC6A4TACR1TACR3 | |
| SCHEMBL8556742 | 0.77 | HSD11B1 (0.61) | TSHRSLC6A4HTR1AHSD11B1HTR1D | |
| SCHEMBL9541312 | 0.74 | TSHR (0.60) | TSHRPTGDR2SLC6A4ACHEHTR1A | |
| SCHEMBL8870741 | 0.73 | TSHR (0.50) | TSHRPTGDR2SLC6A4TACR1TACR3 | |
| SCHEMBL8871409 | 0.71 | KMT2A (0.51) | SLC6A4ACHEHTR1AHSD11B1MPO | |
| SCHEMBL23244251 | 0.70 | ME2 (0.59) | TSHRSLC6A4ACHEHTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693655-A | 3-indolylpiperidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-02 | — | — | US | disclosed |