Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8834199 | 0.88 | GPBAR1 (0.55) | PDE10AALOX5GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL8835183 | 0.83 | PARP10 (0.50) | ALOX5NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL8559028 | 0.81 | PDE10A (0.45) | PDE10AALOX5NPC1RAB9AMAPT | |
| SCHEMBL8557960 | 0.81 | GRM5 (0.41) | ALOX5NPC1RAB9AMAPTKMT2A | |
| SCHEMBL8560309 | 0.80 | KCNH2 (0.39) | PDE10ANPC1RAB9AMAPTGPBAR1 | |
| SCHEMBL8559981 | 0.79 | PARP10 (0.39) | PDE10ANPC1SMN1; SMN2KMT2AFFAR1 | |
| SCHEMBL8555063 | 0.79 | CYSLTR1 (0.42) | ALOX5GPBAR1CYSLTR1CYSLTR2ALOX5AP | |
| SCHEMBL8834730 | 0.79 | PDE10A (0.48) | PDE10AALOX5GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL8552848 | 0.77 | SMPD1 (0.36) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL8559969 | 0.74 | PPARD (0.49) | ALOX5NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714488-A | FOR TREATMENT OF ALLERGIC AND INFLAMMATORY DISEASE STATES | ABBOTT LABORATORIES (US) | 1998-02-03 | — | — | US | disclosed |