Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559981 | 0.89 | PARP10 (0.39) | KCNH2MRGPRX4KDM4EFFAR1PDE10A | |
| SCHEMBL8552848 | 0.85 | SMPD1 (0.36) | POLBKDM4EMAPTRAB9AFFAR1 | |
| SCHEMBL8559969 | 0.84 | PPARD (0.49) | POLBKDM4EMAPTRAB9ANPC1 | |
| SCHEMBL8835183 | 0.83 | PARP10 (0.50) | KCNH2KDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL8557960 | 0.82 | GRM5 (0.41) | POLBKDM4EMAPTRAB9AGRM5 | |
| SCHEMBL8834199 | 0.81 | GPBAR1 (0.55) | FFAR1PDE10AGPBAR1 | |
| SCHEMBL8557729 | 0.80 | PDE10A (0.43) | KDM4EMAPTRAB9AFFAR1PDE10A | |
| SCHEMBL8557961 | 0.75 | MAPT (0.42) | POLBKDM4EMAPTRAB9ANPC1 | |
| SCHEMBL8555063 | 0.75 | CYSLTR1 (0.42) | GPBAR1 | |
| SCHEMBL8559028 | 0.74 | PDE10A (0.45) | KCNH2POLBMAPTRAB9APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714488-A | FOR TREATMENT OF ALLERGIC AND INFLAMMATORY DISEASE STATES | ABBOTT LABORATORIES (US) | 1998-02-03 | — | — | US | disclosed |