Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10883345 | 0.83 | ALDH1A1 (0.37) | ALDH1A1KDM4EALOX5LMNARAB9A | |
| SCHEMBL8557801 | 0.83 | FAAH (0.35) | ALOX5RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL4183804 | 0.83 | GAA (0.39) | ALOX5LMNARAB9ANPC1MAPT | |
| SCHEMBL8554788 | 0.78 | SIRT6 (0.42) | ALDH1A1NPC1MAPTKMT2ATP53 | |
| SCHEMBL19214040 | 0.60 | ELANE (1.00) | ALDH1A1F2ELANECTSGCMA1 | |
| SCHEMBL8559719 | 0.60 | ALOX5 (0.47) | ALDH1A1KDM4EF2ELANECTSG | |
| SCHEMBL456398 | 0.60 | GAA (0.71) | F2ELANECTSGCMA1CTRC | |
| SCHEMBL9645665 | 0.60 | ELANE (0.41) | ALDH1A1KDM4EF2ELANECTSG | |
| SCHEMBL2382690 | 0.57 | ALOX5 (1.00) | ALDH1A1F2ELANECTSGCMA1 | |
| SCHEMBL11734241 | 0.56 | GSK3A (0.57) | ALDH1A1KDM4EF2ELANECTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0756598-B1 | SUBSTITUTED 5,6-DIHYDRO-5-OXO-1,4-DITHIINO-(2,3-D)-PYRIDAZINE-2,3-DICARBONITRILES, COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIMICROBIALS | DOW CHEMICAL CO (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0756598-A1 | SUBSTITUTED 5,6-DIHYDRO-5-OXO-1,4-DITHIINO-(2,3-D)-PYRIDAZINE-2,3-DICARBONITRILES, COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIMICROBIALS | THE DOW CHEMICAL COMPANY (a Delaware corporation) (US) | 1997-02-05 | — | — | EP | disclosed |
| US-5488051-A | BACTERICIDES, FUNGICIDES, ALGICIDES AND ANTIPROTOZOA AGENTS | THE DOW CHEMICAL COMPANY (US) | 1996-01-30 | — | — | US | disclosed |
| WO-1995029181-A1 | SUBSTITUTED 5,6-DIHYDRO-5-OXO-1,4-DITHIINO-(2,3-D)-PYRIDAZINE-2,3-DICARBONITRILES, COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIMICROBIALS | THE DOW CHEMICAL COMPANY (US) | 1995-11-02 | — | — | WO | disclosed |