Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8567179 | 0.80 | HTR1A (0.67) | HTR1ADRD2DRD4ALDH1A1KDM4E | |
| SCHEMBL8566577 | 0.79 | HTR1A (0.42) | HTR1ADRD2DRD4ALDH1A1KDM4E | |
| SCHEMBL8564591 | 0.75 | HTR1A (0.64) | HTR1ADRD2DRD4ALDH1A1NUDT1 | |
| SCHEMBL8570726 | 0.71 | PDE4A (0.42) | HTR1ADRD2DRD4ALDH1A1MAPT | |
| SCHEMBL17302068 | 0.70 | L3MBTL1 (0.41) | HTR1ADRD2DRD4ALDH1A1KDM4E | |
| SCHEMBL11829918 | 0.70 | LMNA (0.46) | HTR1ADRD2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL12495439 | 0.68 | ENPP1 (0.40) | ALDH1A1NUDT1KDM4EMAPTHPGD | |
| SCHEMBL1741595 | 0.67 | LMNA (0.41) | HTR1ADRD2DRD4ALDH1A1KDM4E | |
| SCHEMBL8723876 | 0.66 | HPGD (0.53) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL11298886 | 0.65 | HPGD (0.41) | HTR1ADRD2DRD4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826674-A1 | NOVEL PYRIMIDINE DERIVATIVES EFFICACIOUS AS PSYCHOTROPIC DRUG AND PROCESS FOR THE PRODUCTION THEREOF | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-03-04 | — | — | EP | disclosed |