Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | DRD4 | P21917 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570657 | 0.86 | HTR1A (0.50) | HTR1ADRD2DRD4MEN1KMT2A | |
| SCHEMBL8564897 | 0.83 | HTR1A (0.49) | HTR1ADRD2DRD4MEN1KMT2A | |
| SCHEMBL8565639 | 0.80 | HTR1A (1.00) | HTR1ADRD2DRD4 | |
| SCHEMBL8566577 | 0.79 | HTR1A (0.42) | HTR1ADRD2DRD4MEN1KMT2A | |
| SCHEMBL10920764 | 0.76 | MAPT (0.53) | HTR1ADRD2DRD4MEN1KMT2A | |
| SCHEMBL8566180 | 0.75 | HTR1A (0.41) | HTR1ADRD2DRD4MEN1KMT2A | |
| SCHEMBL8570726 | 0.71 | PDE4A (0.42) | HTR1ADRD2DRD4MAPTALDH1A1 | |
| SCHEMBL3337224 | 0.70 | NUDT1 (0.61) | LMNATDP1NUDT1 | |
| SCHEMBL17302068 | 0.70 | L3MBTL1 (0.41) | HTR1ADRD2DRD4MEN1KMT2A | |
| SCHEMBL10916129 | 0.70 | LMNA (0.49) | HTR1ADRD2DRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826674-A1 | NOVEL PYRIMIDINE DERIVATIVES EFFICACIOUS AS PSYCHOTROPIC DRUG AND PROCESS FOR THE PRODUCTION THEREOF | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-03-04 | — | — | EP | disclosed |