SCHEMBL8573201

SCHEMBL8573201

O=C1c2ccccc2N(c2ccccc2)CN1CCOC1SC(=O)N(Cc2ccccc2)C1=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.37
ALDH1A1 P00352 6/20 0.36
ALDH2 P05091 1/20 0.36
CHRM1 P11229 1/20 0.36
CES1 P23141 1/20 0.36
ALDH3A1 P30838 1/20 0.36
CACNA1G O43497 1/20 0.35
CACNA1H O95180 1/20 0.35
CACNA1I Q9P0X4 1/20 0.35
MAPT P10636 4/20 0.35
THRB P10828 2/20 0.35
ACHE P22303 1/20 0.34
GAA P10253 1/20 0.34
TSHR P16473 2/20 0.33
LRRK2 Q5S007 1/20 0.33
PKM P14618 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
HSD17B10 Q99714 1/20 0.33
GSK3B P49841 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8574464 0.90 ACHE (0.36) POLBALDH1A1ALDH2ALDH3A1MAPT
SCHEMBL8575403 0.90 ALDH1A1 (0.41) POLBALDH1A1ALDH2ALDH3A1MAPT
SCHEMBL8577585 0.89 MAPT (0.37) POLBALDH1A1MAPTTHRBACHE
SCHEMBL8576596 0.88 CACNA1G (0.39) POLBALDH1A1ALDH2CHRM1CES1
SCHEMBL8579010 0.88 POLB (0.34) POLBALDH1A1MAPTTHRBACHE
SCHEMBL8572909 0.87 ADRA1D (0.35) POLBALDH1A1MAPTTHRBGAA
SCHEMBL8575074 0.87 TSHR (0.35) POLBALDH1A1ACHEGAATSHR
SCHEMBL8572953 0.86 CASP1 (0.46) ALDH1A1MAPTACHE
SCHEMBL8573630 0.85 ALDH1A1 (0.40) POLBALDH1A1ALDH2ALDH3A1MAPT
SCHEMBL8574289 0.85 UGCG (0.36) POLBALDH1A1MAPTTHRBACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5710152-A ANTIDIABETIC, ANTILIPEMIC, AND HYPOGLYCEMIC AGENTS; DIETETICS SS PHARMACEUTICAL CO., LTD. (JP) 1998-01-20 US disclosed