Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8602012 | 0.83 | DCTPP1 (0.42) | KDM4EALDH1A1PKN1PKN2KMT2A | |
| SCHEMBL1889761 | 0.80 | KDM4E (0.44) | KDM4EALDH1A1TLR8FBP1KMT2A | |
| SCHEMBL8599822 | 0.78 | ALDH1A1 (0.37) | KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL13318998 | 0.69 | ALDH1A1 (0.52) | KDM4EALDH1A1TLR8FBP1KMT2A | |
| SCHEMBL24774224 | 0.68 | ALDH1A1 (0.46) | KDM4EALDH1A1PKN1PKN2KMT2A | |
| SCHEMBL30952847 | 0.68 | KDM4E (0.46) | KDM4EALDH1A1PKN1PKN2KMT2A | |
| SCHEMBL24744761 | 0.68 | KDM4E (0.46) | KDM4EALDH1A1PKN1PKN2KMT2A | |
| SCHEMBL8598596 | 0.68 | DCTPP1 (0.43) | KDM4EALDH1A1PKN1PKN2KMT2A | |
| SCHEMBL3908139 | 0.68 | KDM4E (0.45) | KDM4EALDH1A1KMT2AHPGDSCN9A | |
| SCHEMBL7016266 | 0.67 | NR1H2 (0.46) | FBP1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |