Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | CTSA | P10619 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819715 | 0.95 | TSHR (0.60) | TSHRCTSAACHETP53TDP1 | |
| SCHEMBL28848779 | 0.88 | TSHR (0.52) | TSHRCTSAACHETP53TDP1 | |
| SCHEMBL17470436 | 0.84 | CYP3A4 (0.52) | TSHR | |
| SCHEMBL22844132 | 0.83 | TSHR (0.46) | TSHRCTSAACHETP53TDP1 | |
| SCHEMBL6899778 | 0.82 | CYP3A4 (0.50) | TSHR | |
| SCHEMBL25991431 | 0.82 | TSHR (0.41) | TSHRCTSAACHETP53TDP1 | |
| SCHEMBL8104926 | 0.81 | TSHR (0.44) | TSHRCTSAACHETP53TDP1 | |
| SCHEMBL6895576 | 0.80 | TSHR (0.55) | TSHRACHETP53TDP1PPARD | |
| SCHEMBL5908843 | 0.80 | TSHR (0.55) | TSHRTP53TDP1PPARDPOLB | |
| SCHEMBL16668638 | 0.80 | TSHR (0.55) | TSHRCTSAACHETP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240016799-A1 | ANTI-INFLAMMATORY, ANTI-CANCER, AND ANTI-ANGIOGENIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF MAKING AND USING THEREOF | MEDICON PHARMACEUTICALS, INC. | 2024-01-18 | — | — | US | disclosed |
| US-11752146-B2 | Anti-inflammatory, anti-cancer, and anti-angiogenic compounds, pharmaceutical compositions, and methods of making and using thereof | MEDICON PHARMACEUTICALS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-10927135-B2 | Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS (US) | 2021-02-23 | — | — | US | disclosed |
| US-10927135-B2 | Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS (US) | 2021-02-23 | — | — | US | disclosed |
| US-20200339598-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2020-10-29 | — | — | US | disclosed |
| US-20200255461-A1 | METAL-FREE DIRECT ARYLATION OF DIALKYL PHOSPHONATES FOR THE SYNTHESIS OF MIXED ALKYL ARYL PHOSPHONATES | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS | 2020-08-13 | — | — | US | disclosed |
| US-20200255461-A1 | METAL-FREE DIRECT ARYLATION OF DIALKYL PHOSPHONATES FOR THE SYNTHESIS OF MIXED ALKYL ARYL PHOSPHONATES | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS | 2020-08-13 | — | — | US | disclosed |
| US-20190152990-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2019-05-23 | — | — | US | disclosed |
| WO-2019028391-A1 | METAL-FREE DIRECT ARYLATION OF DIALKYL PHOSPHONATES FOR THE SYNTHESIS OF MIXED ALKYL ARYL PHOSPHONATES | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS (US) | 2019-02-07 | — | — | WO | disclosed |
| US-20170267639-A1 | Process for Synthesizing Oxidized Lactam Compounds | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2017-09-21 | — | — | US | disclosed |
| US-20090143356-A1 | Polycylclic Carbamoylpyridone Derivative Having HIV Integrase Inhibitory Acitvity | SHIONOGI & CO., LTD. (JP) | 2009-06-04 | — | — | US | disclosed |
| US-20080280905-A1 | UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-11-13 | — | — | US | disclosed |
| US-20080161271-A1 | Bicyclic Carbamoylpyridone Derivative Having Hiv Integrase Inhibitory Activity | SHIONOGI & CO., LTD. (JP) | 2008-07-03 | — | — | US | disclosed |
| US-7388021-B2 | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-06-17 | — | — | US | disclosed |
| US-20070299275-A1 | Method of decomposing organophosphorus compounds | BROWN R S | 2007-12-27 | — | — | US | disclosed |
| WO-2007037134-A9 | INKJET RECORDING MEDIUM AND METHOD FOR MANUFACTURING THE SAME | FUJIFILM CORP (JP) | 2007-05-24 | — | — | WO | disclosed |
| US-7214836-B2 | Method of decomposing organophosphorus compounds | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2007-05-08 | — | — | US | disclosed |
| EP-1613402-A2 | METHOD OF DECOMPOSING ORGANOPHOSPHORUS COMPOUNDS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2006-01-11 | — | — | EP | disclosed |
| US-20040230082-A1 | Method of decomposing organophosphorus compounds | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2004-11-18 | — | — | US | disclosed |
| WO-2004080543-A2 | METHOD OF DECOMPOSING ORGANOPHOSPHORUS COMPOUNDS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299275-A1 | Method of decomposing organophosphorus compounds | ACHE, L3MBTL3, L3MBTL4 | TSHR 2560/4885CTSA 2906/4885ACHE 1/4885 |
| US-20080161271-A1 | Bicyclic Carbamoylpyridone Derivative Having Hiv Integrase Inhibitory Activity | NR4A1, HAT1, NR4A2 | TSHR 3028/4885CTSA 3409/4885ACHE 2605/4885 |
| US-20170267639-A1 | Process for Synthesizing Oxidized Lactam Compounds | COASY, DHPS, OXA1L | TSHR 4488/4885CTSA 4375/4885ACHE 1523/4885 |
| US-20080280905-A1 | UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS | P2RY1, P2RY11, P2RY2 | TSHR 1134/4885CTSA 2466/4885ACHE 3689/4885 |
| US-20040230082-A1 | Method of decomposing organophosphorus compounds | ACHE, L3MBTL3, L3MBTL4 | TSHR 2560/4885CTSA 2906/4885ACHE 1/4885 |
| US-20090143356-A1 | Polycylclic Carbamoylpyridone Derivative Having HIV Integrase Inhibitory Acitvity | CDK20, CYP4A22, CDK10 | TSHR 3929/4885CTSA 4168/4885ACHE 2217/4885 |
| US-20200255461-A1 | METAL-FREE DIRECT ARYLATION OF DIALKYL PHOSPHONATES FOR THE SYNTHESIS OF MIXED ALKYL ARYL PHOSPHONATES | SLC35B2, PPIP5K2, PPA1 | TSHR 733/4885CTSA 3371/4885ACHE 1919/4885 |
| US-20200339598-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY | NR4A1, NCOA4, NR4A2 | TSHR 2821/4885CTSA 3106/4885ACHE 3988/4885 |
| US-10927135-B2 | Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates | SLC35B2, PPIP5K2, PPA1 | TSHR 733/4885CTSA 3371/4885ACHE 1919/4885 |
| US-11752146-B2 | Anti-inflammatory, anti-cancer, and anti-angiogenic compounds, pharmaceutical compositions, and methods of making and using thereof | VEGFA, HPGDS, ALOX5 | TSHR 4882/4885CTSA 117/4885ACHE 402/4885 |
| US-20240016799-A1 | ANTI-INFLAMMATORY, ANTI-CANCER, AND ANTI-ANGIOGENIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF MAKING AND USING THEREOF | VEGFA, HPGDS, ALOX5 | TSHR 4882/4885CTSA 117/4885ACHE 402/4885 |
| US-20190152990-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY | NR4A1, NR4A3, NCOA4 | TSHR 2300/4885CTSA 2675/4885ACHE 3641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.