Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MOK | Q9UQ07 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614064 | 0.89 | ABCB1 (0.50) | ADORA1ADORA3ADORA2AADORA2BMEN1 | |
| SCHEMBL8618123 | 0.86 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AMEN1KMT2A | |
| SCHEMBL8614953 | 0.85 | ALDH1A1 (0.42) | ADORA1ADORA3ADORA2AADORA2BMEN1 | |
| SCHEMBL8618937 | 0.83 | PTGER4 (0.46) | MEN1KMT2AKDM4EALDH1A1ABCB1 | |
| SCHEMBL8615331 | 0.83 | ALDH1A1 (0.41) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL8618655 | 0.82 | PDE10A (0.45) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL8617724 | 0.82 | ABCG2 (0.41) | MEN1KMT2AKDM4EABCB1ABCC1 | |
| SCHEMBL8615265 | 0.81 | MRGPRX1 (0.37) | ADORA1ALDH1A1HPGDABCB1ABCC1 | |
| SCHEMBL8617861 | 0.81 | DHODH (0.42) | ADORA1ABCB1ABCC1ABCG2ACP1 | |
| SCHEMBL8613362 | 0.81 | ACHE (0.41) | MEN1KMT2AKDM4EABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |