Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | IL1RN | P18510 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632286 | 0.91 | KIT (0.45) | IMPDH2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL8629748 | 0.85 | PIK3CA (0.52) | PIK3CASLC22A12TDP1KEAP1GAA | |
| SCHEMBL8632837 | 0.85 | LMNA (0.51) | LMNAKITKDRKDM4EKEAP1 | |
| SCHEMBL8634763 | 0.85 | NAT1 (0.45) | IMPDH2SMN1; SMN2KITKDRKDM4E | |
| SCHEMBL8627973 | 0.85 | KDM1A (0.51) | LMNAKITKDRKDM4ENPSR1 | |
| SCHEMBL8631178 | 0.85 | STAT3 (0.47) | LMNAKITKDRKDM4ENPSR1 | |
| SCHEMBL8632960 | 0.85 | KEAP1 (0.51) | NTRK1LMNASMN1; SMN2KITKDR | |
| SCHEMBL8632208 | 0.83 | STAT3 (0.51) | LMNASMN1; SMN2KEAP1CKS1BSKP2 | |
| SCHEMBL8628203 | 0.82 | ALDH1A1 (0.46) | LMNASMN1; SMN2KITKDRKDM4E | |
| SCHEMBL8631560 | 0.80 | SLC40A1 (0.44) | KITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |