Sugi Predict

Sugi Predict / Compounds / SCHEMBL863124

SCHEMBL863124

SCHEMBL863124

COCCOC(=O)C(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 3/20 0.43
▸ CA12 O43570 1/20 0.38
▸ CA1 P00915 1/20 0.38
▸ CA2 P00918 1/20 0.38
▸ CA9 Q16790 1/20 0.38
▸ ALDH1A1 P00352 4/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ GAA P10253 2/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ POLB P06746 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ THRB P10828 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ RECQL P46063 1/20 0.31
▸ XIAP P98170 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ PLEC Q15149 1/20 0.31
▸ NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11892079 0.93 TSHR (0.39) TSHRCA12CA1CA2CA9
SCHEMBL863284 0.93 TSHR (0.39) TSHRCA12CA1CA2CA9
SCHEMBL12440657 0.93 TSHR (0.39) TSHRCA12CA1CA2CA9
SCHEMBL863123 0.93 TSHR (0.39) TSHRCA12CA1CA2CA9
Ethylene Glycol Diisobutanoate SCHEMBL843146 0.89 TSHR (0.36) TSHRALDH1A1POLBMAPT
SCHEMBL17453513 0.85 ALDH1A1 (0.46) TSHRALDH1A1HPGDRECQL
SCHEMBL2234289 0.85 ALDH1A1 (0.41) TSHRALDH1A1HPGDRECQLKMT2A
SCHEMBL25606392 0.84 TSHR (0.37) TSHRCA12CA1CA2CA9
SCHEMBL20353359 0.83 ALDH1A1 (0.50) TSHRALDH1A1
SCHEMBL20353360 0.83 ALDH1A1 (0.50) TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117551043-A Method for preparing uracil compound containing carboxylic ester fragment by using isocyanate as raw material 江苏中旗科技股份有限公司 2024-02-13 — — CN disclosed
US-11802105-B2 Treprostinil derivatives and compositions and uses thereof Corsair Pharma, Inc. (US) 2023-10-31 — — US disclosed
US-20230287004-A1 SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF SHIONOGI & CO., LTD. (JP) 2023-09-14 — — US disclosed
US-20230194985-A1 BRUSH POLYMER, PHOTORESIST COMPOSITION INCLUDING THE SAME, AND METHOD OF MANUFACTURING INTEGRATED CIRCUIT DEVICE SAMSUNG ELECTRONICS CO., LTD. (KR) 2023-06-22 — — US disclosed
US-20230149562-A1 CARRIERS FOR EFFICIENT NUCLEIC ACID DELIVERY TIBA BIOTECH LLC (US) 2023-05-18 — — US disclosed
US-11639349-B2 Stereoselective synthesis of intermediate for preparation of heterocyclic compound TAIGEN BIOTECHNOLOGY CO., LTD. (TW) 2023-05-02 — — US disclosed
CN-111349185-B Solid catalyst for propylene polymerization and method for producing block copolymer using the same 韩华道达尔能源有限公司 2023-02-03 — — CN disclosed
US-20210127673-A1 HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2021-05-06 — — US disclosed
CN-111349185-A Solid catalyst for propylene polymerization and method for producing block copolymer using the same 韩华道达尔有限公司 2020-06-30 — — CN disclosed
US-20200199266-A1 Solid Catalyst For Propylene Polymerization And Method Of Producing Block Copolymer Using The Same HANWHA TOTALENERGIES PETROCHEMICAL CO., LTD. (KR) 2020-06-25 — — US disclosed
EP-1101761-B1 Process for producing 3-phenyluracil compounds SUMITOMO CHEMICAL CO (JP) 2005-08-17 — — EP disclosed
US-20050059844-A1 Ethynylation process DSM IP ASSETS B.V. (NL) 2005-03-17 — — US disclosed
EP-1432667-A1 ETHYNYLATION PROCESS DSM IP Assets B.V. (NL) 2004-06-30 — — EP disclosed
WO-2003029175-A1 ETHYNYLATION PROCESS DSM IP ASSETS B.V. (NL) 2003-04-10 — — WO disclosed
US-6410484-B1 ACTIVE MATERIAL; CONTROLLING WEEDS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-06-25 — — US disclosed
US-6339155-B1 Process for producing 3-phenyluracil compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-01-15 — — US disclosed
EP-1101761-A2 Process for producing 3-phenyluracil compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-05-23 — — EP disclosed
EP-1095935-A1 6-Hydroxy-5,6-dihydrouracils as herbicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-05-02 — — EP disclosed
CN-1061642-C Preparation of methylglyoxal dimethyl acetal BASF AG (DE) 2001-02-07 — — CN disclosed
CN-1128253-A Preparation of methylglyoxal dimethyl acetal BASF AG (DE) 1996-08-07 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230287004-A1 SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF C3AR1, NR4A1, HAVCR2 TSHR 613/4885CA12 2504/4885CA1 1566/4885
US-11802105-B2 Treprostinil derivatives and compositions and uses thereof PTGIS, PTGIR, PDE3A TSHR 1208/4885CA12 3790/4885CA1 3759/4885
US-11639349-B2 Stereoselective synthesis of intermediate for preparation of heterocyclic compound RNGTT, UNG, NUDT21 TSHR 3709/4885CA12 2986/4885CA1 1408/4885
US-20230149562-A1 CARRIERS FOR EFFICIENT NUCLEIC ACID DELIVERY POLN, TLR9, TSG101 TSHR 3500/4885CA12 2523/4885CA1 3270/4885
US-20210127673-A1 HERBICIDES DDT, HPD, PDXK TSHR 2330/4885CA12 4384/4885CA1 3589/4885
US-20050059844-A1 Ethynylation process F12, CPS1, TTPA TSHR 3201/4885CA12 2698/4885CA1 2863/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.