Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3207157 | 0.93 | HSD17B10 (0.47) | HSD17B10LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL28695929 | 0.86 | HSD17B10 (0.58) | HSD17B10LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7020172 | 0.83 | HSD17B10 (0.50) | HSD17B10LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13241715 | 0.82 | HSD17B10 (0.62) | HSD17B10LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3229064 | 0.81 | HSD17B10 (0.49) | HSD17B10LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL863443 | 0.81 | HTT (0.57) | LMNAALDH1A1MAPTHPGDCYP3A4 | |
| SCHEMBL11317000 | 0.81 | HTT (0.49) | LMNAALDH1A1MAPTHPGDCYP1A2 | |
| SCHEMBL792497 | 0.81 | ALDH1A1 (0.56) | HSD17B10ALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL14439925 | 0.80 | HSD17B10 (0.47) | HSD17B10LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL18216619 | 0.80 | TDP1 (0.58) | LMNASMN1; SMN2ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103140465-B | The method of synthesis 2-methoxymethyl-Isosorbide-5-Nitrae-phenylenediamine | THE PROCTER & GAMBLE CO. (US) | 2015-09-02 | — | — | CN | claimed |
| EP-2621885-B1 | METHODS OF SYNTHESIZING 2-METHOXYMETHYL-1,4-BENZENEDIAMINE | PROCTER & GAMBLE (US) | 2014-10-29 | — | — | EP | claimed |
| US-8759589-B2 | Methods of synthesizing 2-Methoxymethyl-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2014-06-24 | — | — | US | claimed |
| EP-2621885-A1 | METHODS OF SYNTHESIZING 2-METHOXYMETHYL-1,4-BENZENEDIAMINE | The Procter and Gamble Company (US) | 2013-08-07 | — | — | EP | claimed |
| CN-103140465-A | Methods of synthesizing 2-methoxymethyl-1,4-benzenediamine | PROCTER & GAMBLE | 2013-06-05 | — | — | CN | claimed |
| US-20120130128-A1 | Methods of Synthesizing 2-Methoxymethyl-1,4-Benzenediamine | WELLA OPERATIONS US, LLC | 2012-05-24 | — | — | US | claimed |
| WO-2012044758-A1 | METHODS OF SYNTHESIZING 2-METHOXYMETHYL-1,4-BENZENEDIAMINE | THE PROCTER & GAMBLE COMPANY (US) | 2012-04-05 | — | — | WO | claimed |
| EP-2621888-B1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | NOXELL CORP (US) | 2018-09-12 | — | — | EP | disclosed |
| US-9216945-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216945-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216945-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| CN-103140465-B | The method of synthesis 2-methoxymethyl-Isosorbide-5-Nitrae-phenylenediamine | THE PROCTER & GAMBLE CO. (US) | 2015-09-02 | — | — | CN | disclosed |
| EP-2621885-B1 | METHODS OF SYNTHESIZING 2-METHOXYMETHYL-1,4-BENZENEDIAMINE | PROCTER & GAMBLE (US) | 2014-10-29 | — | — | EP | disclosed |
| US-20060287321-A1 | Novel Lactam Derivatives | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-12-21 | — | — | US | disclosed |
| US-20050059651-A1 | Lactam derivatives as antagonists for human 11cby receptors | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-03-17 | — | — | US | disclosed |
| US-5084449-A | Bactericides and antiprotozoa agents | DR. KARL THOMAE GMBH (DE) | 1992-01-28 | — | — | US | disclosed |
| US-4992430-A | Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase | DR. KARL THOMAE GMBH (DE) | 1991-02-12 | — | — | US | disclosed |
| US-4829058-A | INHIBITORS OF BACTERIA, MYCOBACTERIA AND PLASMODIA | DR. KARL THOMAE GMBH (DE) | 1989-05-09 | — | — | US | disclosed |
| EP-0165422-B1 | SUBSTITUTED BIS-(4-AMINOPHENYL)-SULPHONES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1988-03-09 | — | — | EP | disclosed |
| EP-0165422-A1 | Substituted bis-(4-aminophenyl)-sulphones, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1985-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059651-A1 | Lactam derivatives as antagonists for human 11cby receptors | ADRB3, GPR3, ADRB1 | HSD17B10 699/4885LMNA 2857/4885SMN1; SMN2 3783/4885 |
| US-20060287321-A1 | Novel Lactam Derivatives | MRPL21, PEPD, STS | HSD17B10 260/4885LMNA 3313/4885SMN1; SMN2 2924/4885 |
| US-20120130128-A1 | Methods of Synthesizing 2-Methoxymethyl-1,4-Benzenediamine | HNMT, PNMT, BHMT2 | HSD17B10 1256/4885LMNA 3147/4885SMN1; SMN2 1951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.