Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635252 | 0.87 | AKR1C3 (0.50) | PTGS1PTGS2LMNASMN1; SMN2IDH1 | |
| SCHEMBL8633408 | 0.86 | ALDH1A1 (0.39) | PTGS1PTGS2SMN1; SMN2CMA1MAPK13 | |
| SCHEMBL8635463 | 0.86 | AKR1C3 (0.45) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL8632359 | 0.86 | MEN1 (0.44) | PTGS1PTGS2KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL8632107 | 0.85 | AKR1C3 (0.52) | RAPGEF4IDH1 | |
| SCHEMBL8637536 | 0.84 | AKR1C3 (0.51) | PTGS1RAPGEF4LMNASMN1; SMN2IDH1 | |
| SCHEMBL7766528 | 0.83 | SLC9A1 (0.57) | — | |
| SCHEMBL8634318 | 0.83 | PDE4B (0.46) | PTGS1PTGS2KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL8631388 | 0.81 | GAA (0.40) | KCNJ6KCNJ5KCNJ3JAK3SMN1; SMN2 | |
| SCHEMBL8631102 | 0.80 | AKR1C3 (0.47) | KCNJ6KCNJ5KCNJ3LMNAIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057999-C | 4-Aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |
| CN-1138575-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 1996-12-25 | — | — | CN | disclosed |